PT  - JOURNAL ARTICLE
AU  - Terdpong Tanaviriyachai
AU  - Kongtush Choovongkomol
AU  - Patchara Pornsopanakorn
AU  - Sarut Jongkittanakul
AU  - Urawit Piyapromdee
AU  - Weera Sudprasert
TI  - Factors Affecting Neurological Deficits in Thoracic Tuberculous Spondylodiscitis
AID  - 10.14444/8522
DP  - 2023 Oct 01
TA  - International Journal of Spine Surgery
PG  - 645--651
VI  - 17
IP  - 5
4099  - http://ijssurgery.com//content/17/5/645.short
4100  - http://ijssurgery.com//content/17/5/645.full
SO  - Int J Spine Surg2023 Oct 01; 17
AB  - Background Thoracic spinal tuberculosis (TB) causes destruction of the spine and compression of the adjacent spinal cord. This study aimed to identify the risk factors for neurological deterioration in patients with thoracic spinal TB to guide decision-making regarding immediate surgery before the onset of weakness.Methods Demographic, clinical, laboratory, and radiologic (x-ray and magnetic resonance imaging) data of 115 patients with active thoracic spinal TB were retrospectively analyzed. Patients with neurological status categorized as Frankel grades A, B, or C (n = 71) were classified as the neurological deficit group, while those with neurological status categorized as Frankel grades D and E (n = 44) constituted the control group. Univariate and multivariate logistic regression analyses were used to predict the risk factors for neurological deficits.Results The mean patient age was 57.2 years. The most common lesion location was the distal thoracic region (T9-L1; 62.6%). Paradiscal involvement was the most common form of involvement (73%). In the univariate analysis, the significant risk factors associated with neurological worsening were overweight (body mass index [BMI] >25), C-reactive protein level > 20 mg/L, panvertebral involvement, loss of cerebrospinal fluid posterior to the cord, cord signal changes, and canal compromise. The multivariate analysis revealed that only BMI >25 (adjusted OR = 16.18; 95% CI 1.60–163.64; P = 0.018), cord signal changes (adjusted OR = 7.42; 95% CI 1.85–29.74; P = 0.005), and canal encroachment >50% ( adjusted OR = 51.86; 95% CI 5.53–486.24; P = 0.001) were independent risk factors for predicting the risk of neurological deficits.Conclusions Overweight (BMI >25), cord signal changes, and canal compromise >50% significantly predicted neurological deficits in patients with thoracic spinal TB. Prompt spinal surgery should be considered before progressive worsening of the neurological condition in patients with all of these risk factors.Clinical Relevance Predictive factors for neurological deficits in thoracic spinal TB were determined. Overweight, cord signal changes, and canal compromise >50% showed predictive value. These factors can help identify patients who require early surgical intervention.Level of Evidence 3.