Overall success and components of success for CDA and ACDF at 10 years.
| Outcome | CDA | ACDF | P Valuea | Difference |
| Composite success | 62.4% (51.2%, 72.6%) | 22.2% (10.1%, 39.2%) | <0.0001 | 40.1%b (23.9%, 56.4%) |
| Neurologic success | 87.8% (78.2%, 94.3%) | 55.6% (35.3%, 74.5%) | 0.0015 | 32.3%b (17.8%, 46.8%) |
| Subsequent surgery | 8.2% (3.4%, 16.2%) | 33.3% (18.6%, 51.0%) | 0.0017 | 25.1%b (12.5%, 37.7%) |
| Treatment-related serious adverse event | 2.4% (0.3%, 8.2%) | 11.1% (3.1%, 26.1%) | 0.06 | 8.8%c (−0.1%, 18.1%) |
| Neck Disability Index success | 84.8% (75.0%, 91.9%) | 74.1% (53.7%, 88.9%) | 0.25 | 10.7%c (−2.3%, 23.8%) |
Note: Data presented as overall success rate (95% CI).
Significant P values indicated in bold.
↵a Fisher’s exact test comparing CDA vs ACDF at 10 y.
↵b Superiority of CDA vs ACDF with 95% lower confidence bound of difference >0%.
↵c Noninferiority of CDA vs ACDF with 95% lower confidence bound of difference >−10%.
ACDF, anterior cervical discectomy and fusion; CDA, cervical disc arthroplasty.