Table 1

Inclusion and Exclusion Criteria.

Undergoing thoracic and/or lumbar spinal surgery for correction of any adult deformity via posterior spinal fusion (including TLIF or PLIF)Significant medical history preventing the use of TXA as described in this protocol
Greater than 6 vertebral levelsCurrent use of anticoagulant medication or past medical history leading to an abnormal coagulation profile preoperatively
Age 18 to 80History of renal failure or elevated creatinine above 1.4
Male or FemaleHistory of thromboembolic event (DVT or PE) within last year
History of seizures
Religious or other beliefs limiting blood transfusion