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Parametric T2 and T2* mapping techniques to visualize intervertebral disc degeneration in patients with low back pain: initial results on the clinical use of 3.0 Tesla MRI

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Abstract

Objective

To assess, compare and correlate quantitative T2 and T2* relaxation time measurements of intervertebral discs (IVDs) in patients suffering from low back pain, with respect to the IVD degeneration as assessed by the morphological Pfirrmann Score. Special focus was on the spatial variation of T2 and T2* between the annulus fibrosus (AF) and the nucleus pulposus (NP).

Materials and Methods

Thirty patients (mean age: 38.1 ± 9.1 years; 20 female, 10 male) suffering from low back pain were included. Morphological (sagittal T1-FSE, sagittal and axial T2-FSE) and biochemical (sagittal T2- and T2* mapping) MRI was performed at 3 Tesla covering IVDs L1–L2 to L5–S1. All IVDs were morphologically classified using the Pfirrmann score. Region-of-interest (ROI) analysis was performed on midsagittal T2 and T2* maps at five ROIs from anterior to posterior to obtain information on spatial variation between the AF and the NP. Statistical analysis-of-variance and Pearson correlation was performed.

Results

The spatial variation as an increase in T2 and T2* values from the AF to the NP was highest at Pfirmann grade I and declined at higher Pfirmann grades II–IV (p < 0.05). With increased IVD degeneration, T2 and T2* revealed a clear differences in the NP, whereas T2* was additionally able to depict changes in the posterior AF. Correlation between T2 and T2* showed a medium Pearson’s correlation (0.210 to 0.356 [p < 0.001]).

Conclusion

The clear differentiation of IVD degeneration and the possible quantification by means of T2 and fast T2* mapping may provide a new tool for follow-up therapy protocols in patients with low back pain.

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References

  1. Andersson GB. Epidemiology of low back pain. Acta Orthop Scand. 1998;281:28–31.

    CAS  Google Scholar 

  2. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26:1873–8.

    Article  PubMed  CAS  Google Scholar 

  3. Schiebler ML, Camerino VJ, Fallon MD, Zlatkin MB, Grenier N, Kressel HY. In vivo and ex vivo magnetic resonance imaging evaluation of early disc degeneration with histopathologic correlation. Spine. 1991;16:635–40.

    Article  PubMed  CAS  Google Scholar 

  4. Mosher TJ, Dardzinski BJ. Cartilage MRI T2 relaxation time mapping: overview and applications. Semin Musculoskelet Radiol. 2004;8:355–68.

    Article  PubMed  Google Scholar 

  5. Watanabe A, Benneker LM, Boesch C, Watanabe T, Obata T, Anderson SE. Classification of intervertebral disk degeneration with axial T2 mapping. AJR Am J Roentgenol. 2007;189:936–42.

    Article  PubMed  Google Scholar 

  6. Bittersohl B, Hosalkar HS, Hughes T, et al. Feasibility of T2* mapping for the evaluation of hip joint cartilage at 1.5 T using a three-dimensional (3D), gradient-echo (GRE) sequence: a prospective study. Magn Reson Med. 2009;62:896–901.

    Article  PubMed  Google Scholar 

  7. Welsch GH, Trattnig S, Hughes T, et al. T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation: initial results on clinical use with 3.0-Tesla MRI. Eur Radiol 2010;20:1515–23

    Article  PubMed  Google Scholar 

  8. Schultz DS, Rodriguez AG, Hansma PK, Lotz JC. Mechanical profiling of intervertebral discs. J Biomech. 2009;42:1154–7.

    Article  PubMed  Google Scholar 

  9. Chiu EJ, Newitt DC, Segal MR, Hu SS, Lotz JC, Majumdar S. Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro. Spine. 2001;26:E437–44.

    Article  PubMed  CAS  Google Scholar 

  10. Krueger EC, Perry JO, Wu Y, Haughton VM. Changes in T2 relaxation times associated with maturation of the human intervertebral disk. AJNR Am J Neuroradiol. 2007;28:1237–41.

    Article  PubMed  CAS  Google Scholar 

  11. Perry J, Haughton V, Anderson PA, Wu Y, Fine J, Mistretta C. The value of T2 relaxation times to characterize lumbar intervertebral disks: preliminary results. AJNR Am J Neuroradiol. 2006;27:337–42.

    PubMed  CAS  Google Scholar 

  12. Niinimäki J, Ruohonen J, Silfverhuth M, Lappalainen A, Kaapa E, Tervonen O. Quantitative magnetic resonance imaging of experimentally injured porcine intervertebral disc. Acta Radiol. 2007;48:643–9.

    Article  PubMed  Google Scholar 

  13. Marinelli NL, Haughton VM, Munoz A, Anderson PA. T2 relaxation times of intervertebral disc tissue correlated with water content and proteoglycan content. Spine. 2009;34:520–4.

    Article  PubMed  Google Scholar 

  14. Quirbach S, Trattnig S, Marlovits S, et al. Initial results of in vivo high-resolution morphological and biochemical cartilage imaging of patients after matrix-associated autologous chondrocyte transplantation (MACT) of the ankle. Skeletal Radiol. 2009;38:751–60.

    Article  PubMed  Google Scholar 

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Acknowledgement

Funding for this study was provided by the Austrian Science Fund (FWF) Translational Research Project L494 and the Vienna Advanced Clinical Imaging Center (VIACLIC) program.

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Correspondence to Siegfried Trattnig.

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Welsch, G.H., Trattnig, S., Paternostro-Sluga, T. et al. Parametric T2 and T2* mapping techniques to visualize intervertebral disc degeneration in patients with low back pain: initial results on the clinical use of 3.0 Tesla MRI. Skeletal Radiol 40, 543–551 (2011). https://doi.org/10.1007/s00256-010-1036-8

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  • DOI: https://doi.org/10.1007/s00256-010-1036-8

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