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Factors influencing early postoperative complications following surgery for symptomatic spinal metastasis: a single-center series and multivariate analysis

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Abstract

Patients presenting with neurological deficits and/or pain due to spinal metastasis usually require immediate or subacute surgical treatment. Nevertheless, it is unclear whether or not side effects of primary cancer location might influence postoperative complication rate. We therefore analyzed our spinal database to identify factors influencing early postoperative complications after surgery for symptomatic spinal metastases. From 2013 to 2017, 163 consecutive patients suffering from symptomatic spinal metastases were treated at our department. Early postoperative complications were defined as any postoperative event requiring additional medical or surgical treatment within 30 days of spinal surgery. A multivariate regression analysis was performed to identify independent predictors for postoperative complications after surgery for spinal metastasis. Overall, 39 of 163 patients who underwent spinal surgery for spinal metastasis developed early postoperative complications throughout the treatment course (24%). Preoperative ASA score ≥ 3 (p = 0.003), preoperative C-reactive protein level > 10 mg/l (p = 0.008), preoperative Karnofsky Performance Score < 60% (p = 0.03), radiation treatment within 2 months of surgery (p = 0.01), presence of diabetes mellitus (p = 0.008), and preoperative complete neurological impairment (p = 0.04) were significant and independent predictors for early postoperative complications in patients with surgery for spinal metastasis. The ability to preoperatively predict postoperative complication risk is valuable to select critically ill patients at higher risk requiring special attention. Therefore, the present study identified several significant and independent risk factors for the development of early postoperative complication in patients who underwent surgery for spinal metastasis.

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Authors and Affiliations

  1. Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany

    Patrick Schuss, Ági Güresir, Matthias Schneider, Hartmut Vatter & Erdem Güresir

  2. Department of Anesthesiology and Intensive Care Medicine, Rheinische Friedrich-Wilhelms-University Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany

    Markus Velten

Authors
  1. Patrick Schuss
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  2. Ági Güresir
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  3. Matthias Schneider
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  4. Markus Velten
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  5. Hartmut Vatter
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  6. Erdem Güresir
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Correspondence to Patrick Schuss.

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The authors declare that they have no conflicts of interest.

Ethical approval

The present study was approved by the local ethics committee of the University of Bonn (092/18).

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Informed consent was not sought as a retrospective study design was used.

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Schuss, P., Güresir, Á., Schneider, M. et al. Factors influencing early postoperative complications following surgery for symptomatic spinal metastasis: a single-center series and multivariate analysis. Neurosurg Rev 43, 211–216 (2020). https://doi.org/10.1007/s10143-018-1032-3

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  • DOI: https://doi.org/10.1007/s10143-018-1032-3

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