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Biologic adjuvants and bone: current use in orthopedic surgery

  • Biological Adjuvants in Orthopedic Surgery (J Dines and D Grande, Section Editors)
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Abstract

Normal bone healing is a complex process that eventually restores original structure and function to the site of trauma. However, clinical circumstances such as nonunion, critical-sized defects, systemic bone disease, and fusion procedures have stimulated a search for ways to enhance this normal healing process. Biologics are an important part of this search and many, including bone marrow aspirate concentrate, demineralized bone matrix, platelet-rich plasma, bone morphogenic proteins, and platelet-derived growth factor, are currently in clinical use. Many others, including mesenchymal stem cells, parathyroid hormone, and Nel-like molecule-1 (NELL-1) will likely be in use in the future depending on the results of preclinical and clinical trials.

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Benjamin Smith, Todd Goldstein, and Charles Ekstein declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Department of Orthopedic Surgery and Orthopedic Research Laboratory, Feinstein Institute for Medical Research and North Shore-LIJ Health System, Manhasset, NY, USA

    Benjamin Smith, Todd Goldstein & Charles Ekstein

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  1. Benjamin Smith
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  2. Todd Goldstein
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  3. Charles Ekstein
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Correspondence to Benjamin Smith.

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This article is part of the Topical Collection on Biological Adjuvants in Orthopedic Surgery

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Smith, B., Goldstein, T. & Ekstein, C. Biologic adjuvants and bone: current use in orthopedic surgery. Curr Rev Musculoskelet Med 8, 193–199 (2015). https://doi.org/10.1007/s12178-015-9265-z

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