Total disc replacement has become an option for the treatment of degenerative disc disease of the lumbar spine. A new generation of implants has been developed that can be implanted through minimally invasive anterior approaches to the lumbar levels L2/3, L3/4, L4/5 and L5/S1. However mid- and long-term data are still lacking. This paper describes the minimally invasive surgical approach - techniques as well as the preliminary results of our first 34 consecutive patients. The intervertebral spaces L5/S1, L4/5, L3/4 and L2/3 were each approached through slightly different, but standardized, mini-laparotomies either through a retroperitoneal or a transperitoneal route. The clinical results with a follow-up of up to 1 year show satisfactory outcomes in about 80% of the patients. Oswestry score as well as VAS values show significant changes during the postoperative course. There have been three complications (8.8%), two of which were specific to the implantation process, but were resolved with a good clinical outcome in both patients. The preliminary results suggest that total disc replacement may become a reasonable alternative to spinal fusion under the selection criteria used in this study.