Study design: Long-term evaluation was performed for bioabsorbable poly-L-lactic acid cages in a goat interbody fusion model.
Objective: To assess the radiographic, histologic, and histomorphometric characteristics of poly-L-lactic acid cages during 3 years of follow-up evaluation.
Summary of background data: Failed cage fusions may be related to cage design and material in addition to the surgical technique used. To overcome material-related complications and to explore the potential benefits of bioabsorbable cages, poly-L-lactic acid cages have been designed.
Methods: For this study, 36 Dutch milk goats underwent a lumbar interbody fusion procedure (L3-L4). Two types of custom-made cage devices were impacted with bone graft and implanted: poly-L-lactic acid cages (n = 30) and titanium cages (n = 6). Sequential harvesting of surgically managed motion segments (intervals: 3, 6, 12, 24, and 36 months) was performed for analysis.
Results: In poly-L-lactic acid specimens, permanent interbody fusion could be achieved within 6 months after surgery with maintenance of cage height. Titanium specimens showed no interbody fusion within this period. Radiographic follow-up evaluation (6-36 months) showed interbody fusion in 86% (19/22) of poly-L-lactic acid specimens, as compared with 33% (2/6) of titanium specimens. After 36 months of implantation, in one half of the specimens, poly-L-lactic acid cages were completely absorbed. Bone histomorphometry showed complete bone remodeling after 2 years of follow-up evaluation. During the study period, no local or distant adverse histologic effects were observed.
Conclusions: The current study showed that poly-L-lactic acid cage devices are feasible for lumbar interbody fusion. New poly-L-lactic acid cages designed for clinical practice might be a viable alternative to current nonabsorbable cage devices.