An ideal and realistic finite-element analysis should include several factors, such as geometry (shape and size), the relative volumes of the nucleus to the anulus fibrosus, the fiber volume fraction within the anulus, and material properties. In this study, a finite-element analysis model for the disc that included these factors was developed. In addition, synthetic disc prostheses with the same specifications of geometry and material properties were manufactured. The developed model was found to be reliable and accurate when finite-element analysis results were compared with experimental synthetic disc data. The model also matched the mechanical behavior of the natural disc. This finite-element analysis model provides a tool to study the mechanical behavior of discs with varying degrees and types of injury and degeneration.