Abstract
Kaposiform hemangioendothelioma is a rare vascular tumor of childhood that is locally aggressive but has little metastatic potential and by itself is not known to be lethal. It most commonly presents as a superficial or deep soft tissue mass with associated cutaneous lesions. Kasabach-Merritt phenomenon, a condition characterized by profound thrombocytopenia and life-threatening hemorrhage, often is associated with kaposiform hemangioendothelioma. Six cases of kaposiform hemangioendothelioma have been reported in bone, two of which were located in extracraniofacial bones. We report a diagnostically challenging case of a 6-year-old girl with kaposiform hemangioendothelioma of the thoracolumbar spine without Kasabach-Merritt phenomenon or cutaneous lesions.
MeSH terms
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Angiogenesis Inhibitors / therapeutic use
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Biomarkers, Tumor / analysis
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Celecoxib
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Child
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Drug Therapy, Combination
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Female
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Hemangioendothelioma / complications
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Hemangioendothelioma / drug therapy
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Hemangioendothelioma / pathology*
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Humans
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Lumbar Vertebrae / diagnostic imaging
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Lumbar Vertebrae / pathology
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Pain / etiology
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Platelet Endothelial Cell Adhesion Molecule-1 / analysis
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Pyrazoles / therapeutic use
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Radiography
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Sarcoma, Kaposi / complications
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Sarcoma, Kaposi / drug therapy
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Sarcoma, Kaposi / pathology*
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Spinal Neoplasms / complications
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Spinal Neoplasms / drug therapy
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Spinal Neoplasms / pathology*
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Sulfonamides / therapeutic use
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Syndrome
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Thalidomide / therapeutic use
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Thoracic Vertebrae / diagnostic imaging
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Thoracic Vertebrae / pathology
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Treatment Outcome
Substances
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Angiogenesis Inhibitors
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Anti-Inflammatory Agents, Non-Steroidal
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Biomarkers, Tumor
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Platelet Endothelial Cell Adhesion Molecule-1
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Pyrazoles
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Sulfonamides
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Thalidomide
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Celecoxib