In order to evaluate the sensitivity of hepatocellular cultures to variations in both substrate
stiffness and bioactive ligand presentation, hepatocytes were cultured on differentially …

Since effective cell sourcing is a major challenge for the therapeutic management of liver
disease and liver failure, embryonic stem (ES) cells are being widely investigated as a …

Background The use of acellular dermal matrices (ADMs) has become the standard of
practice in many reconstructive and aesthetic surgical applications. Different methods used to …

We examined the effects of co-cultivated hepatocytes on the hepatospecific differentiation of
murine embryonic stem (ES) cells. Utilizing an established mouse ES cell line expressing …

Background: Acellular dermal matrices (ADMs) are frequently used in reconstructive surgery
and as scaffolds to treat chronic wounds. The 3-dimensional architecture and extracellular …

Purpose Viable cartilage allograft (VCA) is a cartilage tissue matrix that contains cryopreserved
viable allogeneic cartilage fibres. This study aimed to assess safety and benefits in …

Although cadherin-mediated intercellular contacts can be integral to the maintenance of
functionally competent hepatocytes in vitro, the ability to engineer hepatocellular differentiated …

Background: To evaluate the comparative abilities of commercially available, viable, cellular
bone allografts to promote posterolateral spinal fusion. Methods: Human allografts …

… I would also like to dedicate this thesis to my loving family: my mother, Banani Dasgupta, my
brother, Dr. Arijit Dasgupta and my sister, Surupa Dasgupta. Thank you for all your patience …

… In addition, I am very grateful to Anouska Dasgupta, Colette Ranucci, and Tom Brieva for …
I would especially like to thank Anouska, who has shared a cubicle space with me for the last …