Tissue-engineered approaches for the treatment of early-stage intervertebral disc degeneration
have shown promise in preclinical studies. However, none of these therapies has been …

Study Design: Systematic review. Objective: To date there is no consensus among surgeons
as to what defines an MIS-TLIF (transforaminal lumbar interbody fusion using minimally …

Innovative technology and techniques have revolutionized minimally invasive spine surgery
(MIS) within the past decade. The introduction of navigation and image-guided surgery has …

Objective The aim is assessing the in vivo efficacy of annulus fibrosus (AF) cells seeded into
collagen by enhancing the reparative process around annular defects and preventing …

BACKGROUND Sagittal alignment is an important consideration in spine surgery. The
literature is conflicted regarding the effect of minimally invasive transforaminal lumbar interbody …

Background Reconstruction of large cranial defects after craniectomy can be accomplished
by free-hand poly-methyl-methacrylate (PMMA) or industrially manufactured implants. The …

BACKGROUND Our group has previously demonstrated in vivo annulus fibrosus repair in
animal models using an acellular, riboflavin crosslinked, high-density collagen (HDC) gel. …

Background: In patients with symptomatic lumbar stenosis undergoing lateral transpsoas
approach for lumbar interbody fusion (LLIF) surgery, it is not always clear when indirect …

Minimally invasive surgical approaches for the treatment of spinal pathologies have
accelerated over the past three decades and resulted in superior functional outcomes with less …

Background One of the longest-standing treatments to prevent delayed cerebral infarction (DCI)
in patients with aneurysmal subarachnoid hemorrhage (aSAH) remains raising the …