Effect of porosity on the fluid flow characteristics and mechanical properties of tantalum scaffolds

DA Shimko, VF Shimko, EA Sander… - … Research Part B …, 2005 - Wiley Online Library
In many cases of traumatic bone injury, bone grafting is required. The primary source of graft
material is either autograft or allograft. The use of both material sources are well established…

Development and characterization of a porous poly (methyl methacrylate) scaffold with controllable modulus and permeability

DA Shimko, EA Nauman - … : An Official Journal of The Society …, 2007 - Wiley Online Library
Functional restoration following extensive bone injury often requires bone grafting. The primary
source of graft material is either autograft or allograft. The use of both material sources is …

Oxidatively degradable poly (thioketal urethane)/ceramic composite bone cements with bone-like strength

…, KJ Zienkiewicz, JC Wenke, KN Kalpakci, DA Shimko… - RSC …, 2016 - pubs.rsc.org
Synthetic bone cements are commonly used in orthopaedic procedures to aid in bone
regeneration following trauma or disease. Polymeric cements like PMMA provide the mechanical …

Nanocrystalline hydroxyapatite–poly (thioketal urethane) nanocomposites stimulate a combined intramembranous and endochondral ossification response in rabbits

…, JC Wenke, C Rhodes, D Shimko… - ACS biomaterials …, 2019 - ACS Publications
Resorbable bone cements are replaced by bone through osteoclastic resorption and
osteoblastic new bone formation near the periphery. However, the ideal bone cement would be …

Comparative efficacy of commonly available human bone graft substitutes as tested for posterolateral fusion in an athymic rat model

…, S Mohan, E Vasquez, D Shimko… - International Journal of …, 2019 - ijssurgery.com
Background: Insufficient data exist on bone graft substitute materials efficacy; two thirds lack
any clinical data. This prospective animal study identified efficacy differences among …

Comparison of in Vitro Mineralization by Murine Embryonic and Adult Stem Cells Cultured in an Osteogenic Medium

DA Shimko, CA Burks, KC Dee, EA Nauman - Tissue engineering, 2004 - liebertpub.com
Nearly half a million bone-grafting procedures occurred in the United States in the year 2000.
Tissue- engineered bone substitutes may mitigate difficulties associated with current …

A Device for Long Term, In Vitro Loading of Three-Dimensional Natural and Engineered Tissues

DA Shimko, KK White, EA Nauman, KC Dee - Annals of biomedical …, 2003 - Springer
In vitro studies of mechanical loads applied to three-dimensional tissue constructs are
important to the design and production of functional, engineered bone tissue. This study reports …

Effects of recombinant human bone morphogenetic protein-2 dose and ceramic composition on new bone formation and space maintenance in a canine mandibular …

AD Talley, KN Kalpakci, DA Shimko… - … Engineering Part A, 2016 - liebertpub.com
Treatment of mandibular osseous defects is a significant clinical challenge. Maintenance of
the height and width of the mandibular ridge is essential for placement of dental implants …

Remodeling of injectable, low‐viscosity polymer/ceramic bone grafts in a sheep femoral defect model

…, KJ Zienkiewicz, DA Shimko… - … Research Part B …, 2017 - Wiley Online Library
Ceramic/polymer composite bone grafts offer the potential advantage of combining the
osteoconductivity of ceramic component with the ductility of polymeric component, resulting in a …

Injectable, compression‐resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model

…, LA Boller, KN Kalpakci, DA Shimko… - Clinical oral implants …, 2018 - Wiley Online Library
Objective The objective of this study was to test the hypothesis that a compression‐resistant
bone graft augmented with recombinant human morphogenetic protein‐2 (rhBMP‐2) will …