Decades of work have aimed to genetically reprogram T cells for therapeutic purposes 1 , 2
using recombinant viral vectors, which do not target transgenes to specific genomic sites 3 , …

Two murine lysosome-associated membrane proteins, LAMP-1 of 105,000-115,000 D and
LAMP-2 of 100,000-110,000 D, have been identified by monoclonal antibodies that bind …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored. Use
of this technique in patients with acute brain injury has increased our understanding of the …

Objective: To review the efficacy, safety, pharmacology and pharmacokinetics of pure, plant-derived
cannabidiol (CBD; Epidiolex) in the treatment of Dravet syndrome (DS) and Lennox-…

✓ The authors prospectively used a new hand-held point-and-shoot pupillometer to assess
pupillary function quantitatively. Repetitive measurements were initially made in more than …

To survey high-volume hip arthroscopists regarding their current indications for labral
reconstruction, graft preference and technique. In May 2018, a cross-sectional based survey was …

Background Age-related macular degeneration (AMD) is the leading cause of vision loss in
elderly people over 60. The pathogenesis is still unclear. It has been suggested that …

Myeloid cells assemble inflammasomes in response to infection or cell damage; cytosolic
sensors activate pro–caspase-1, indirectly for the most part, via the adaptors ASC and NLRC4. …

Most surgeons rely on the greater trochanter as the reference point to establish the anterolateral
portal. Nevertheless, we believe that the anterosuperior iliac spine is a more reliable …

Immunofluorescence microscopy of cultured animal cells is often performed after detergent
permeabilization of formaldehyde-fixed cellular membranes so that antibodies may have …