Background This is the first randomised controlled trial for assessment of the immunogenicity
and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 …

Background A vaccine to protect against COVID-19 is urgently needed. We aimed to assess
the safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 (Ad5) …

Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across
many research fields. We explored bird macroevolution using full genomes from 48 avian …

Copy number variants (CNVs) are associated with changes in gene expression levels and
contribute to various adaptive traits 1 , 2 . Here we show that a CNV at the Grain Length on …

Two-dimensional materials provide extraordinary opportunities for exploring phenomena
arising in atomically thin crystals. Beginning with the first isolation of graphene, mechanical …

Mimicking certain features (eg nanoscale topography and biological cues) of natural
extracellular matrix (ECM) is advantageous for the successful regeneration of damaged tissue. In …

Motivation Although long-read sequencing technologies can produce genomes with long
contiguity, they suffer from high error rates. Thus, we developed NextPolish, a tool that …

Anode‐free solid‐state lithium batteries are promising for next‐generation energy storage
systems, especially the mobile sectors, due to their enhanced energy density, improved safety, …

Currently, the success of gene therapy is mainly limited due to the lack of effective vector
systems. Although viral vectors are highly efficient in transfecting cells, undesirable …

Chitosans have been proposed as biocompatible alternative cationic polymers that are suitable
for non-viral delivery. However, the transfection efficiency of chitosan-DNA nanoparticles …