Use of immune checkpoint inhibitors targeting the programmed cell death protein-1/programmed
cell death-ligand 1 and cytotoxic T lymphocyte-associated protein-4 axes has yielded …

Exosomes (versatile, cell-derived nanovesicles naturally endowed with exquisite target-homing
specificity and the ability to surmount in vivo biological barriers) hold substantial promise …

Objective: To perform an individual participant data meta-analysis using randomized trials
and propensity-score matched (PSM) studies which compared laparoscopic versus open …

Background Metabolic–bariatric surgery delivers substantial weight loss and can induce
remission or improvement of obesity-related risks and complications. However, more robust …

Machine learning algorithms are a powerful tool in healthcare, but sometimes perform no
better than traditional statistical techniques. Steps should be taken to ensure that algorithms …

The tyrosine kinase inhibitors (TKIs) directed at sensitizing mutations in the epidermal
growth factor receptor (EGFR) gene represents a critical pillar in non-small cell lung cancer …

PURPOSE The US Food and Drug Administration has granted regulatory approval for the
use of nivolumab—an immune checkpoint inhibitor (ICI)—in the first-line treatment of …

Major advances with the development of epidermal growth factor receptor tyrosine kinase
inhibitors and immune check-point inhibitors have ushered in a new era in lung cancer therapy…

Background The exact role of laparoscopic liver resection (LLR) in patients with hepatocellular
carcinoma (HCC) and underlying liver cirrhosis (LC) is not well defined. In this meta-…

Antimicrobial peptides (AMPs) are a pervasive and evolutionarily ancient component of innate
host defense which is present in virtually all classes of life. In recent years, evidence has …