Over the last 50 years, we argue that incentives for academic scientists have become
increasingly perverse in terms of competition for research funding, development of quantitative …

The p53 tumor suppressor protein is stabilized in response to ionizing radiation and accumulates
in the nucleus. Stabilization is thought to involve disruption of the interaction between …

The PHD finger protein 1 (PHF1) is essential in epigenetic regulation and genome maintenance.
Here we show that the Tudor domain of human PHF1 binds to histone H3 trimethylated …

Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular
homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases …

Natural products are important sources of anti-cancer lead molecules. Many successful anti-cancer
drugs are natural products or their analogues. Many more are under clinical trials. …

In April 2014, the drinking water source in Flint, Michigan was switched from Lake Huron water
with phosphate inhibitors to Flint River water without corrosion inhibitors. The absence of …

Metal/ceramic composites are in high demand in several industries because of their superior
thermo-mechanical properties. Among various composite types, the interpenetrating phase …

A systematic review of the various aspects of internal load transfer using different diffraction-based
methods has been carried out in this work to strengthen the understanding of metal …

The p53 tumor suppressor protein is regulated by multiple post-translational modifications,
including lysine methylation. We previously found that monomethylation of p53 at lysine 382 (…

Background: There is a large degree of variation in tumour response and host toxicities
associated with neoadjuvant chemoradiation for rectal cancer patients. We performed a …