The aging of the global population: the changing epidemiology of disease and spinal disorders

…, T Choma, J Harrop, T Mroz, C Santaguida… - …, 2015 - journals.lww.com
The global population is currently undergoing an upward shift in its age structure due to
decreasing fertility rates and increasing life expectancy. As a result, clinicians worldwide will be …

[HTML][HTML] Neural stem/progenitor cells from the adult human spinal cord are multipotent and self-renewing and differentiate after transplantation

AJ Mothe, T Zahir, C Santaguida, D Cook, CH Tator - PloS one, 2011 - journals.plos.org
Neural stem/progenitor cell (NSPC) transplantation is a promising therapy for spinal cord
injury (SCI). However, little is known about NSPC from the adult human spinal cord as a donor …

Systemic and topical use of tranexamic acid in spinal surgery: a systematic review

SF Winter, C Santaguida, J Wong… - Global Spine …, 2016 - journals.sagepub.com
Study Design Combination of narrative and systematic literature reviews. Objectives Massive
perioperative blood loss in complex spinal surgery often requires blood transfusions and …

Laminectomy and fusion versus laminoplasty for the treatment of degenerative cervical myelopathy: results from the AOSpine North America and International …

MG Fehlings, C Santaguida, L Tetreault, P Arnold… - The spine journal, 2017 - Elsevier
Background Context It remains unclear whether cervical laminoplasty (LP) offers advantages
over cervical laminectomy and fusion (LF) in patients undergoing posterior decompression …

[HTML][HTML] Single-cell RNA sequencing reveals time-and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

…, N Brown, L Haglund, J Ouellet, C Santaguida… - Nature …, 2022 - nature.com
Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether distinct …

Safety and efficacy of riluzole in patients undergoing decompressive surgery for degenerative cervical myelopathy (CSM-Protect): a multicentre, double-blind, placebo …

…, ST Yoon, KD Kim, DR Fourney, C Santaguida… - The Lancet …, 2021 - thelancet.com
Background Degenerative cervical myelopathy represents the most common form of non-traumatic
spinal cord injury. This trial investigated whether riluzole enhances outcomes in …

[HTML][HTML] Continuous monitoring of surgical bimanual expertise using deep neural networks in virtual reality simulation

…, N Ledwos, AM Fazlollahi, C Santaguida… - NPJ Digital …, 2022 - nature.com
In procedural-based medicine, the technical ability can be a critical determinant of patient
outcomes. Psychomotor performance occurs in real-time, hence a continuous assessment is …

Association between paraspinal muscle morphology, clinical symptoms, and functional status in patients with degenerative cervical myelopathy

…, M Courtemanche, CJ Sparrey, C Santaguida… - Spine, 2017 - journals.lww.com
Study Design. A cross-sectional study. Objective. The aim of this study was to assess fatty
infiltration and asymmetry of the multifidus (MF), semispinalis cervicis (SCer), semispinalis …

Clinical and pathological outcomes after resection of intramedullary spinal cord tumors: a single-institution case series

N Samuel, L Tetreault, C Santaguida, A Nater… - Neurosurgical …, 2016 - thejns.org
OBJECTIVE The objective of this study was to identify clinically relevant predictors of
progression-free survival and functional outcomes in patients who underwent surgery for …

The state-of-the-art in ultrasound-guided spine interventions

HE Gueziri, C Santaguida, DL Collins - Medical Image Analysis, 2020 - Elsevier
During the last two decades, intra-operative ultrasound (iUS) imaging has been employed
for various surgical procedures of the spine, including spinal fusion and needle injections. …