Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth
…, RS Prather, J Zabner, DC Fredericks… - Proceedings of the …, 2010 - National Acad Sciences
People with cystic fibrosis (CF) exhibit growth defects. That observation has been attributed,
in part, to decreased insulin-like growth factor 1 (IGF1) levels, and the reduction has been …
in part, to decreased insulin-like growth factor 1 (IGF1) levels, and the reduction has been …
Effects of pulsed electromagnetic fields on bone healing in a rabbit tibial osteotomy model
DC Fredericks, JV Nepola, JT Baker… - … of orthopaedic trauma, 2000 - journals.lww.com
Objective: The purpose of this study was to determine the effect of pulsed electromagnetic
field (PEMF) exposure on healing tibial osteotomies in New Zealand White rabbits. Design: …
field (PEMF) exposure on healing tibial osteotomies in New Zealand White rabbits. Design: …
Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis
We tested whether inhibiting mechanically responsive articular chondrocyte mitochondria
after severe traumatic injury and preventing oxidative damage represent a viable paradigm for …
after severe traumatic injury and preventing oxidative damage represent a viable paradigm for …
Regeneration of bone using nanoplex delivery of FGF-2 and BMP-2 genes in diaphyseal long bone radial defects in a diabetic rabbit model
…, E Petersen, B Guetschow, DC Fredericks… - Journal of controlled …, 2017 - Elsevier
Bone fracture healing impairment related to systemic diseases such as diabetes can be
addressed by growth factor augmentation. We previously reported that growth factors such as …
addressed by growth factor augmentation. We previously reported that growth factors such as …
Instability dependency of osteoarthritis development in a rabbit model of graded anterior cruciate ligament transection
Background: Joint instability has long been empirically recognized as a leading risk factor
for osteoarthritis. However, formal mechanistic linkage of instability to osteoarthritis …
for osteoarthritis. However, formal mechanistic linkage of instability to osteoarthritis …
Biomechanical analysis of cervical disc replacement and fusion using single level, two level, and hybrid constructs
…, NM Grosland, JD Smucker, DC Fredericks - Spine, 2015 - journals.lww.com
Study Design. A biomechanical study comparing arthroplasty with fusion using human
cadaveric C2–T1 spines. Objective. To compare the kinematics of the cervical spine after …
cadaveric C2–T1 spines. Objective. To compare the kinematics of the cervical spine after …
Vertical shear injuries: is there a relationship between residual displacement and functional outcome?
…, SL Butterfield, DC Fredericks… - Journal of Trauma …, 1999 - journals.lww.com
Background Residual vertical displacement is often cited as being related to poor outcome
in patients with pelvic injuries. This study attempts to clarify the relationship between residual …
in patients with pelvic injuries. This study attempts to clarify the relationship between residual …
Characteristics of meniscus progenitor cells migrated from injured meniscus
…, AD Lehman, KW Jang, DC Fredericks… - Journal of …, 2017 - Wiley Online Library
Serious meniscus injuries seldom heal and increase the risk for knee osteoarthritis; thus,
there is a need to develop new reparative therapies. In that regard, stimulating tissue …
there is a need to develop new reparative therapies. In that regard, stimulating tissue …
Effects of pulsed electromagnetic field stimulation on distraction osteogenesis in the rabbit tibial leg lengthening model
DC Fredericks, DJ Piehl, JT Baker… - Journal of pediatric …, 2003 - journals.lww.com
The purpose of this study was to determine whether exposure to pulsed electromagnetic
field (PEMF) would shorten the healing time of regenerate bone in a rabbit tibial distraction …
field (PEMF) would shorten the healing time of regenerate bone in a rabbit tibial distraction …
Time‐dependent loss of mitochondrial function precedes progressive histologic cartilage degeneration in a rabbit meniscal destabilization model
JE Goetz, MC Coleman, DC Fredericks… - Journal of …, 2017 - Wiley Online Library
The goals of this work were to characterize progression of osteoarthritic cartilage degeneration
in a rabbit medial meniscus destabilization (MMD) model and then to use the model to …
in a rabbit medial meniscus destabilization (MMD) model and then to use the model to …