Peptidoglycan (PG) is a polysaccharide matrix that protects bacteria from osmotic lysis.
Inhibition of its biogenesis is a proven strategy for killing bacteria with antibiotics. The assembly …

Cryptococcal meningitis is common in sub-Saharan Africa. Given the need for data for a
rapid, point-of-care cryptococcal antigen (CRAG) lateral flow immunochromatographic assay (…

The ability to rapidly identify diseases enables prompt treatment and improves outcomes.
This possibility has increased the development and use of rapid point-of-care diagnostic …

Overexpression or mutation of α-Synuclein is associated with protein aggregation and interferes
with a number of cellular processes, including mitochondrial integrity and function. We …

Abstract Treatment of chronic hepatitis B (CHB) patients with nucleos (t) ide analogs (NAs)
suppresses hepatitis B virus (HBV) DNA synthesis but does not affect synthesis of HBV …

Objective According to recent estimates, at least 11% of the total global burden of disease is
attributable to surgically-treatable diseases. In children, the burden is even more striking …

Purpose Little is known about the prevalence of pediatric surgical conditions in low- and
middle-income countries. Many children never seek medical care, thus the true prevalence of …

Objectives: To determine if higher fresh frozen plasma and platelet to packed RBC ratios
are associated with lower 24-hour mortality in bleeding pediatric trauma patients. Design: …

Gram-negative bacteria such as Escherichia coli build a peptidoglycan (PG) cell wall in their
periplasm using the precursor known as lipid II. Lipid II is a large amphipathic molecule …

Staphylococcus aureus encodes the Sec-independent Ess secretion pathway, an ortholog
of mycobacterial T7 secretion systems which is required for the virulence of this Gram-positive …