Mechanochemical manipulation of hepatocyte aggregation can selectively induce or repress liver‐specific function

EJ Semler, CS Ranucci… - Biotechnology and …, 2000 - Wiley Online Library
Controlled activation of hepatocyte aggregation is critical to three‐dimensional (3D)
multicellular morphogenesis during native regeneration of liver as well as tissue reconstruction …

Engineering hepatocellular morphogenesis and function via ligand‐presenting hydrogels with graded mechanical compliance

EJ Semler, PA Lancin, A Dasgupta… - Biotechnology and …, 2005 - Wiley Online Library
In order to evaluate the sensitivity of hepatocellular cultures to variations in both substrate
stiffness and bioactive ligand presentation, hepatocytes were cultured on differentially …

Engineering hepatocyte functional fate through growth factor dynamics: the role of cell morphologic priming

EJ Semler, PV Moghe - Biotechnology and bioengineering, 2001 - Wiley Online Library
We have reported previously that cellular stimulation induced by variable mechanochemical
properties of the extracellular microenvironment can significantly alter liver-specific function …

Analysis of surface microtopography of biodegradable polymer matrices using confocal reflection microscopy

EJ Semler, JS Tjia, PV Moghe - Biotechnology progress, 1997 - Wiley Online Library
Currently, synthetic degradable polymers are frequently employed as culture substrates prior
to cell transplantation and as implantable scaffolds for cellular infiltration during soft and …

Comparing cellular bone matrices for posterolateral spinal fusion in a rat model

…, EI Waldorff, P Punsalan, D Wang, E Semler… - JOR …, 2020 - Wiley Online Library
Introduction Cellular bone matrices (CBM) are allograft products that provide three
components essential to new bone formation: an osteoconductive scaffold, extracellular growth …

Association of 3-dimensional cartilage and bone structure with articular cartilage properties in and adjacent to autologous osteochondral grafts after 6 and 12 months …

EF Chan, IL Liu, EJ Semler, HM Aberman… - Cartilage, 2012 - journals.sagepub.com
Objective: The articular cartilage of autologous osteochondral grafts is typically different in
structure and function from local host cartilage and thereby presents a remodeling challenge. …

Tissue assembly guided via substrate biophysics: Applications to hepatocellular engineering

EJ Semler, CS Ranucci, PV Moghe - Tissue Engineering I, 2006 - Springer
The biophysical nature of the cellular microenvironment, in combination with its biochemical
properties, can critically modulate the outcome of three-dimensional (3-D) multicellular …

Cytomimetic engineering of hepatocyte morphogenesis and function by substrate-based presentation of acellular E-cadherin

EJ Semler, A Dasgupta, PV Moghe - Tissue Engineering, 2005 - liebertpub.com
Although cadherin-mediated intercellular contacts can be integral to the maintenance of
functionally competent hepatocytes in vitro, the ability to engineer hepatocellular differentiated …

Composition and Bioactivity of a Placental Tissue Particulate (PTP-001) Indicate Greater Potential than Platelet-Rich Plasma for the Treatment of Osteoarthritis

…, L Begum, MA Nasert, B Catalfamo, EJ Semler… - Cartilage, 2023 - journals.sagepub.com
Objective This study was conducted to compare therapeutically relevant properties of platelet-rich
plasma (PRP), a commonly used autologous intra-articular treatment for osteoarthritis (…

A comparative evaluation of commercially available cell-based allografts in a rat spinal fusion model

…, N Zhang, EI Waldorff, E Semler… - International Journal of …, 2020 - ijssurgery.com
Background: To evaluate the comparative abilities of commercially available, viable, cellular
bone allografts to promote posterolateral spinal fusion. Methods: Human allografts …