To identify new immortalizing genes with potential roles in tumorigenesis, we performed a
genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts …

Necroptosis, a regulated necrosis pathway mediated by the receptor-interacting protein kinases
1 and 3 (RIPK1 and RIPK3), is induced following spinal cord injury (SCI) and thought to …

Primary fibroblasts respond to activated H-RAS V12 by undergoing premature arrest, which
resembles replicative senescence 1 . This irreversible 'fail-safe mechanism' requires p19 …

BCR/ABL, the oncoprotein responsible for chronic myeloid leukemia (CML), transforms
hematopoietic cells through both Ras-dependent and -independent mechanisms. Farnesyl …

The autophagy–lysosomal pathway plays an essential role in cellular homeostasis as well
as a protective function against a variety of diseases including neurodegeneration. …

Many mouse models of breast cancer form large primary tumors that rarely metastasize.
Models with aggressive metastasis express oncoproteins that simultaneously affect growth and …

The Akt, Ras and STAT5 signaling pathways have each been linked to transformation of
hematopoietic cells by BCR/ABL. However the relative contributions of these signaling …

Study Design: Meta-analysis of evidence level I to IV studies. Objective: To compare
decompression alone versus decompression plus fusion in the treatment of grade I degenerative …

Study Design. A comparative study of facet joint violation (FJV) using two percutaneous
surgical techniques. Objective. To compare the rate of iatrogenic FJV and medial pedicle wall …

During differentiation in vitro, Embryonic Stem (ES) cells generate both primitive erythroid and
definitive myeloid lineages in a process that mimics hematopoiesis in the mammalian yolk …