Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although
inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 …

Introduction The modern literature is producing a rapidly growing number of articles which
highlight the relationship between infection and lumbar disc degeneration. However, the …

The regulation of T cell and DC retention and lymphatic egress within and from the intestine
is critical for intestinal immunosurveillance; however, the cellular processes that orchestrate …

Background. Methicillin-resistant Staphylococcus aureus (MRSA) has become a major health
threat in the United States. Staphylococcal enterotoxin B (SEB) is a potent superantigen …

This study aims to investigate the quantitative and qualitative differences between freehand
and bipolar experimental knapping products of quartzite from Olduvai Gorge, Tanzania. A …

Treatment of inflammatory bowel disease (IBD) generally relies on long-term use of anti-inflammatory
and immunosuppressive agents. The adverse effects of those drugs make it …

Background. Staphylococcal enterotoxin B (SEB), a potential biological warfare agent, is a
potent superantigen that contributes to the virulence of methicillin-resistant Staphylococcus …

The past decade has seen an abundance of new mouse models that mimic the human
inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis. These mouse models …

Mouse and human data implicate the NOD1 and NOD2 sensors of the intestinal microbiome
and the associated signal transduction via the receptor interacting protein kinase 2 (RIPK2) …

Introduction Deep wound infection after spinal surgery is a potentially devastating
complication and is associated with higher morbidity, mortality and healthcare costs. Different …