Cellular roles of DNA topoisomerases: a molecular perspective

JC Wang - Nature reviews Molecular cell biology, 2002 - nature.com
Wang, JC Interaction between DNA and an Escherichia coli protein ω. J. Mol. … & Wang,
JC Bacterial DNA topoisomerase I can relax positively supercoiled DNA containing a single-…

Supercoiling of the DNA template during transcription.

LF Liu, JC Wang - Proceedings of the National Academy of …, 1987 - National Acad Sciences
Transcription of a right-handed double-helical DNA requires a relative rotation of the RNA
polymerase and its nascent RNA around the DNA. We describe conditions under which the …

Functional properties of novel proteins: Alfalfa leaf protein

JC Wang, JE Kinsella - Journal of food science, 1976 - Wiley Online Library
Functional properties of protein concentrates from alfalfa leaves (ALP) prepared by several
methods were determined. Minimum solubilities occurred around pH 3.5–4; sodium chloride …

β-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression

SY Lin, W Xia, JC Wang, KY Kwong… - Proceedings of the …, 2000 - National Acad Sciences
β-Catenin can function as an oncogene when it is translocated to the nucleus, binds to T cell
factor or lymphoid enhancer factor family members, and transactivates its target genes. In …

DNA topoisomerases

JC Wang - Annual review of biochemistry, 1996 - annualreviews.org
JC Wang, unpublished results). The sources of these discrepancies are intriguing; plausible
causes are the presence of other factors in the topoisomerase preparations, different states …

DNA topoisomerases

JC Wang - Annual review of biochemistry, 1985 - annualreviews.org
Biochemical studies of the enzymes have complemented genetic analysis of their functions
and regulation. Studies on poly-ADP-ribosylation and phos phorylation of topoisomerases …

Interaction between DNA and an Escherichia coli protein ω

JC Wang - Journal of molecular biology, 1971 - Elsevier
… (a) Assay of w Covalently closed cyclic hb265c DNA containing variable number of
superhelical turns were prepared as described previously (Wang, 1969a). In most of the assays, a …

Structure and mechanism of DNA topoisomerase II

JM Berger, SJ Gamblin, SC Harrison, JC Wang - Nature, 1996 - nature.com
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped
dimeric protein with a large central hole. It provides a molecular model of the …

Adjacent segment degeneration in the lumbar spine

G Ghiselli, JC Wang, NN Bhatia, WK Hsu, EG Dawson - JBJS, 2004 - journals.lww.com
Background: A primary concern after posterior lumbar spine arthrodesis is the potential for
adjacent segment degeneration cephalad or caudad to the fusion segment. There is …

Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence

JC Wang, M Bennett - Circulation research, 2012 - Am Heart Assoc
Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …