Study Design. Randomized controlled trial. Objective. Analyze the clinical outcomes at 5
years comparing cervical total disc replacement (TDR) with ProDisc-C (Synthes Spine USA …

Background: In patients with single-level cervical degenerative disc disease, total disc
arthroplasty can relieve radicular pain and preserve functional motion between two vertebrae. We …

Object The purpose of this study was to evaluate the long-term safety and effectiveness of
the ProDisc-L total disc replacement (TDR) as part of an FDA-mandated postmarket approval …

… Radcliff K, Zigler J, Zigler J. Costs of cervical disc replacement versus anterior cervical …
Jack Zigler receives royalties from Zimmer Sine, and has taught and consulted for DePuy …

Background: Disc replacement arthroplasty previously has been shown to be an effective
alternative to spine fusion for the treatment of single-level lumbar degenerative disc disease. …

There is an increasing population of immunocompromised patients with HIV, IV drug abuse,
organ transplantation, and long-term steroid treatment developing spinal infections. Delayed …

… Acquisition of data: Zigler, Glenn. Analysis and interpretation of data: all authors. Drafting …
: Zigler. Statistical analysis: Zigler, Delamarter. Administrative/technical/material support: …

This study represents the first 39 patients with at least 6-month follow-up enrolled in a
prospective randomized Food and Drug Administration study evaluating the safety and efficacy of …

Study Design: Systematic literature review with meta-analysis. Objective: Osteoporosis is
common in elderly patients, who frequently suffer from spinal fractures or degenerative …

Study Design. A Markov state-transition model was developed to evaluate the cost-effectiveness
of anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (CDR) …