… van Rhijn contributed to section 1 and 4 and shared his long-standing expertise as orthopedic
surgeon; Pieter J. Emans greatly contributed to all sections of this review and shared his …

Background: Hallux rigidus is a common cause of foot pain in the elderly and has a negative
impact on quality of life. Several operative treatment options are available for feet that are …

Background: Focal cartilage defects are often debilitating, possess limited potential for
regeneration, are associated with increased risk of osteoarthritis, and are predictive for total knee …

OBJECTIVE: Three-dimensional (3D) cultures are widely used to redifferentiate chondrocytes.
However, the rationale behind the choice for 3D above two-dimensional (2D) cultures is …

Artificial disc prosthesis show fair to good short- and mid-term results. Long-term results are
becoming apparent now, however, the incidence of late complications with this procedure …

OBJECTIVE: Bone morphogenic protein (BMP)-2 and BMP-7 are clinically approved and
their recombinant proteins are used for bone tissue regenerative purposes and widely …

Treatment of full-thickness damage to hyaline cartilage is hampered by the limited
availability of autologous healthy cartilage and the lengthy, cost-prohibitive cell isolation and …

Background Gut barrier loss has been implicated as a critical event in the occurrence of
postoperative complications. We aimed to study the development of gut barrier loss in patients …

In this study, we investigated the potential of celecoxib-loaded polyester amide (PEA)
microspheres as an auto-regulating drug delivery system for the treatment of pain associated with …

Background context Surgery for adult spinal deformity is a challenging and complex procedure
with high reported complication (8.4%–42%) and revision rates (9%–17.6%). Failure to …