TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

LW Shen, HJ Mao, YL Wu, Y Tanaka, W Zhang - Biochimie, 2017 - Elsevier
Influenza virus and coronavirus epidemics or pandemics have occurred in succession
worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat …

[HTML][HTML] γδ T cells and their potential for immunotherapy

YL Wu, YP Ding, Y Tanaka, LW Shen… - … journal of biological …, 2014 - ncbi.nlm.nih.gov
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset,
recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous …

[HTML][HTML] Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons

…, WY Shen, X Wang, CX Zhao, WX Li… - Neural regeneration …, 2020 - journals.lww.com
The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury.
However, it is unclear whether deferoxamine directly protects neurons from ferroptotic cell …

Using asphaltene supermolecules derived from coal for the preparation of efficient carbon electrodes for supercapacitors

WH Qu, YB Guo, WZ Shen, WC Li - The Journal of Physical …, 2016 - ACS Publications
Asphaltene supermolecules extracted from coal consist of highly condensed polyaromatic
units and peripheral aliphatic chains, which is a natural source with high carbon content. In …

Prediction of relative displacement for entry roof with weak plane under the effect of mining abutment stress

W Shen, J Bai, W Li, X Wang - Tunnelling and Underground Space …, 2018 - Elsevier
In coal mining, the entry roof with a weak plane (ERWP) is vulnerable to large relative
displacement, and even caving influenced by the mining stress from the adjacent working face (…

[HTML][HTML] The impact of artificial intelligence on health equity in oncology: scoping review

P Istasy, WS Lee, A Iansavichene, R Upshur… - Journal of medical …, 2022 - jmir.org
Background The field of oncology is at the forefront of advances in artificial intelligence (AI)
in health care, providing an opportunity to examine the early integration of these …

[HTML][HTML] Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 …

LW Shen, MQ Qian, K Yu, S Narva, F Yu, YL Wu… - Scientific Reports, 2020 - nature.com
Proteolytic cleavage of influenza A virus (IAV) hemagglutinin by host proteases is crucial for
virus infectivity and spread. The transmembrane serine protease TMPRSS2 was previously …

Diastereoselective Construction of Cyclopropane-Fused Tetrahydroquinolines via a Sequential [4+ 2]/[2+ 1] Annulation Reaction

ZH Wang, LW Shen, KX Xie, Y You, JQ Zhao… - Organic …, 2020 - ACS Publications
A sequential [4 + 2]/[2 + 1] annulation of α-aryl vinylsulfoniums with 2-aminochalcones and 2-(2-aminobenzylidene)-1H-indene-1,3(2H)-dione
is reported that affords a series of …

Access to 4-Trifluoromethyl Quinolines via Cu-Catalyzed Annulation Reaction of Ketone Oxime Acetates with ortho-Trifluoroacetyl Anilines under Redox-Neutral …

ZH Wang, LW Shen, P Yang, Y You… - The Journal of …, 2022 - ACS Publications
An efficient Cu-catalyzed annulation reaction of ketone oxime acetates with ortho-trifluoroacetyl
anilines has been disclosed. With the developed protocol, a series of 4-trifluoromethyl …

Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging

F Zhang, TT Sun, Y Zhang, Q Li, C Chai, L Lu… - Journal of materials …, 2014 - pubs.rsc.org
Magnetic quantum dots (MQDs) are an important class of agents for fluorescence (FL)/magnetic
resonance (MR) dual-modal imaging due to their excellent optical and magnetic …