Just as neuronal activity is essential to normal brain function, microtubule-associated protein
tau appears to be critical to normal neuronal activity in the mammalian brain, especially in …

Hyperphosphorylated tau has long been proposed as the key molecule disrupting normal
neuronal microtubule dynamics and leading to neurofibrillary degeneration in Alzheimer …

… -ASF or GST (0.2 mg/ml) was incubated with various concentrations of Dyrk1A in a reaction
buffer consisting of 50 mm Tris-HCl (pH 7.4), 10 mm β-mercaptoethanol, 0.1 mm EGTA, 10 …

The activity of protein phosphatase (PP)-2A, which regulates tau phosphorylation, is compromised
in Alzheimer disease brain. Here we show that the transient transfection of PC12 cells …

Pharmacological enhancement of hippocampal neurogenesis is a therapeutic approach for
improvement of cognition in learning and memory disorders such as Alzheimer's disease. …

Purpose Maximum two-dimensional (2D) diameter has been used to define giant pituitary
adenoma (GPA) surgery outcomes as has volume using an ellipsoid approximation of …

Glutamate toxicity through NMDA receptor channels has long been central to the
understanding of acute neuronal injury. Recent studies implicate similar events in chronic …

Introduction Fluorescence guided surgery (FGS) with five-aminolevulinic acid (5-ALA) is
expected to revolutionize neurosurgical care of patients with high-grade gliomas (HGG). After …

Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote
neurogenesis and maturation of newborn cells into mature functional neurons represents an …

A therapeutic strategy against cognitive disorders like Alzheimer's disease is to take advantage
of the regenerative ability of the brain and the properties of neurotrophic factors to shift …