Metal debris from implants has been shown to alter the function of osteoblasts in cell cultures.
Its remains unclear, however, if specific forms of released ionic metals are involved in the …

® Implant degradation products have been shown to be associated with dermatitis, urticaria,
and vasculitis. If cutaneous signs of an allergic response appear after implantation of a …

There is an increasing recognition that, in the long term, total joint replacement may be
associated with adverse local and remote tissue responses that are mediated by the degradation …

Biologic response to orthopedic implants debris is central to clinical performance. Eventual
implant loosening due to aseptic osteolysis has been attributed to local inflammatory …

How lymphocyte‐mediated metal sensitivity affects orthopaedic implant performance remains
poorly understood. Do patients with implants exhibit elevated lymphocyte reactivity to …

Directed cell adhesion remains an important goal of implant and tissue engineering
technology. In this study, surface energy and surface roughness were investigated to ascertain …

Since the recognition of aseptic loosening by Charnley in the early 1960s, much information
has been gained on the basic science of periprosthetic bone loss. Initially termed cement …

Background The central and peripheral inflammatory response to surgery may influence
patient outcomes. This study examines the time course and clinical relevance of changes in …

In the majority of patients, orthopaedic implants are biocompatible. However, there is an
increasing recognition that, in the long-term, permanent orthopaedic implants may be …

Immune reactivity to soluble and particulate implant debris remains the primary cause of
aseptic inflammation and implant loosening. However, the intracellular mechanisms that trigger …