The Na-K-ATPase is characterized by a complex molecular heterogeneity that results from the
expression and differential association of multiple isoforms of both its α- and β-subunits. At …

… Mercer's present address is the Department of Human Genetics, Yale University School of …
active flux that can be obtained in intact cells (Mercer and Dunham, 1981 [in press]; JR Sachs, …

The gamma subunit of the Na,K-ATPase is a small membrane protein that copurifies with
the alpha and beta subunits of the enzyme. Strong evidence that the gamma subunit is a …

Pluripotent mouse embryonic stem cells (ESCs) derived from the early blastocyst can
differentiate in vitro into a variety of somatic cell types including lineages from all three embryonic …

Different isoforms of the sodium/potassium adenosinetriphosphatase (Na,K-ATPase) α and
β subunits have been identified in mammals. The association of the various α and β …

The Na, K-ATPase is a membrane-associated enzyme responsible for maintaining the high
internal K concentration and low internal Na concentration characteristic of most animal cells…

The nonsense-mediated mRNA decay (NMD) pathway selectively eliminates aberrant
transcripts containing premature translation termination codons and regulates the levels of a …

In addition to the three isoforms of the catalytic subunit of the Na,K-ATPase originally identified
(α1, α2, and α3), a fourth α polypeptide (α4) has recently been found in mammalian cells. …

While several studies have investigated the regulation of the Na,K-ATPase consisting of the
α1 and β1 subunits, there is little evidence that intracellular messengers influence the other …

… The /3 subunit is a type II glycoprotein with a molecular mass of 40—60 kDa (Mercer, 1993).
Although the exact function of the (3 subunit is unclear, the subunit is required for normal …