Silicon micromachining provides the precise control of nanoscale features that can be
fundamentally enabling for miniaturized, implantable medical devices. Concerns have been …

The rapid understanding of the cellular and molecular bases of organ function and disease
processes will be translated in the next decade into new therapeutic approaches to a wide …

Polydimethylsiloxane (PDMS Sylgard ® 184, Dow Corning Corporation) pre-polymer was
combined with increasing amounts of cross-linker (5.7, 10.0, 14.3, 21.4, and 42.9 wt.%) and …

Medical devices based on microelectro-mechanical systems (MEMS) platforms are currently
being proposed for a wide variety of implantable applications. However, biocompatibility …

Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …

When pressure is applied to a localized area of the body for an extended time, the resulting
loss of blood flow and subsequent reperfusion to the tissue causes cell death and a pressure …

Background Remote monitoring of patients with heart failure (HF) using wearable devices
can allow patient-specific adjustments to treatments and thereby potentially reduce …

The fabrication of multi-level SU-8 microstructures using multiple coating and exposure steps
and a single developing step has been achieved for up to six layers of SU-8. Alternating …

Background Chronic kidney disease (CKD) is a major cause of early death worldwide. By
2030, 14.5 million people will have end‐stage kidney disease (ESKD, or CKD stage 5), yet …

Most of the 400,000+ patients in the United States with kidney failure depend on dialysis
treatments in dedicated dialysis centers for 3 h to 5 h, usually 3 times a week, but they still suffer …