In mice, gonads are formed shortly before embryonic day 10.5 by the thickening of the
mesonephros and consist of somatic cells and migratory primordial germ cells 1 . The male sex-…

The Cre‐loxP strategy provides an approach to disrupt genes in specific tissues and/or cell
types, circumventing lethality associated with global knockouts or secondary effects due to …

Mash1 is a transcription factor required during embryogenesis for the development of multiple
neural lineages. It is expressed in restricted domains at specific stages in the developing …

Potassium (K + ) channels are involved in the modulation and fine tuning of the excitable
properties of neurons and glia in the nervous system. In the present report, in situ hybridization …

OBJECTIVE: To determine if improvements in pain after epidural steroid injections (ESIs)
were related to electromyographic (EMG) findings in patients with radicular symptoms and …

… and prepared for injection as previously described (Verma-Kurvari … in olfactory
epithelium has never been detected even with the largest transgenic constructs (Verma-Kurvari …

We have employed gene knockout technology in mice to probe gene function in various
stages of mouse male sexual differentiation. Insulin‐like factor (Insl3) is prominently expressed …

Background Lumbar interbody fusion has long been used for the treatment of painful
degenerative spinal conditions. The anterior approach is not feasible in some patients, and the …

Proteins of the achaete–scute family of transcription factors play important roles in neurogenesis
in both invertebrates and vertebrates. Here, we report the cloning and characterization …

The gubernaculum is a mesenchymal tissue that connects the gonads to the inguinal abdominal
wall in the mammalian embryo. During gestation in the male, differential development of …