[HTML][HTML] Evidence for infection in intervertebral disc degeneration: a systematic review
I Granville Smith, NP Danckert, MB Freidin… - European Spine …, 2022 - Springer
Purpose Back pain is a major problem worldwide and is linked to intervertebral disc
degeneration and Modic change. Several studies report growth of bacteria following …
degeneration and Modic change. Several studies report growth of bacteria following …
The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review
Many factors may trigger intervertebral disc (IVD) structural failure (intervertebral disc
degeneration (IDD) and endplate changes), including inflammation, infection, dysbiosis, and …
degeneration (IDD) and endplate changes), including inflammation, infection, dysbiosis, and …
[PDF][PDF] For whom the disc tolls: intervertebral disc degeneration, back pain and toll-like receptors
Intervertebral disc (IVD) degeneration is characterised by catabolic and inflammatory
processes that contribute largely to tissue degradation and chronic back pain. The disc cells …
processes that contribute largely to tissue degradation and chronic back pain. The disc cells …
[HTML][HTML] Pro-inflammatory and neurotrophic factor responses of cells derived from degenerative human intervertebral discs to the opportunistic pathogen …
MN Capoor, A Konieczna, A McDowell… - International Journal of …, 2021 - mdpi.com
Previously, we proposed the hypothesis that similarities in the inflammatory response
observed in acne vulgaris and degenerative disc disease (DDD), especially the central role …
observed in acne vulgaris and degenerative disc disease (DDD), especially the central role …
[HTML][HTML] Molecular detection of Propionibacterium acnes in biopsy samples of intervertebral disc with modic changes in patients undergoing herniated disc surgery
S Najafi, P Mahmoudi, SA Bassampour… - Iranian journal of …, 2020 - ncbi.nlm.nih.gov
Materials and Methods: Thirty-seven patients who were candidates for surgery due to disc
herniation and demonstrated Modic changes in MRI were included in the study. Before the …
herniation and demonstrated Modic changes in MRI were included in the study. Before the …
Cutibacterium (Formerly Propionibacterium) acnes Keratitis: A Review
NS Ashby, TJ Johnson, Y Castillo-Ronquillo… - Eye & Contact …, 2023 - journals.lww.com
Infectious keratitis is a devastating cause of vision loss worldwide. Cutibacterium acnes (C.
acnes), a commensal bacterium of the skin and ocular surface, is an underrecognized but …
acnes), a commensal bacterium of the skin and ocular surface, is an underrecognized but …
[HTML][HTML] Colonization of intervertebral discs by Cutibacterium acnes in patients with low back pain: Protocol for an analytical study with microbiological, phenotypic …
V Magno da Rocha, COGX Lima, EO Ferreira… - Plos one, 2023 - journals.plos.org
Lumbar disc degeneration (LDD) and low back pain (LBP) are two conditions that are
closely related. Several studies have shown Cutibacterium acnes colonization of …
closely related. Several studies have shown Cutibacterium acnes colonization of …
Risk factors associated with low-grade virulent infection in intervertebral disc degeneration: a systematic review and meta-analysis
M Zhang, J Jia, L Deng, Z Cao, X Hu, S Lei, G Zhang… - The Spine Journal, 2024 - Elsevier
Background An increasing number of research indicates an association between low-grade
bacterial infections, particularly those caused by Propionibacterium acnes (P. acnes), and …
bacterial infections, particularly those caused by Propionibacterium acnes (P. acnes), and …
[HTML][HTML] Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain
LG Czaplewski, M Zeitlinger, JF Standing - npj Antimicrobials and …, 2023 - nature.com
Oral coamoxiclav and amoxicillin, for extended dose regimens of up to 100 days, have
shown benefit in the treatment of Chronic Lower Back Pain (CLBP) associated with vertebral …
shown benefit in the treatment of Chronic Lower Back Pain (CLBP) associated with vertebral …
[HTML][HTML] Sheep as a Potential Model of Intradiscal Infection by the Bacterium Cutibacterium acnes
The anaerobic bacterium Cutibacterium acnes has been increasingly linked to the
development of degenerative disc disease (DDD), although causality is yet to be …
development of degenerative disc disease (DDD), although causality is yet to be …
