Recent advances in the local antibiotics delivery systems for management of osteomyelitis

RK Wassif, M Elkayal, RN Shamma, SA Elkheshen - Drug delivery, 2021 - Taylor & Francis
Chronic osteomyelitis is a challenging disease due to its serious rates of mortality and
morbidity while the currently available treatment strategies are suboptimal. In contrast to the …

Hot topics on vertebral osteomyelitis from the International Society of Antimicrobial Chemotherapy

K Saeed, S Esposito, T Ascione, M Bassetti… - International journal of …, 2019 - Elsevier
Vertebral osteomyelitis (VO), also known as spondylodiscitis, describes infections of the
vertebrae and intervertebral discs. Discitis describes infection limited to the intervertebral …

[HTML][HTML] Conservative versus early surgical treatment in the management of pyogenic spondylodiscitis: a systematic review and meta-analysis

SG Thavarajasingam, KV Vemulapalli, S Vishnu K… - Scientific reports, 2023 - nature.com
Spondylodiscitis is the commonest spine infection, and pyogenic spondylodiscitis is the most
common subtype. Whilst antibiotic therapy is the mainstay of treatment, some advocate that …

Pyogenic spondylodiscitis: The quest towards a clinical-radiological classification.

H Almansour, W Pepke, M Akbar - Der Orthopade, 2020 - europepmc.org
Background Pyogenic spondylodiscitis (PS) is a debilitating condition laden with orthopedic
and neurological complications. The choice of the best step in management is often delayed …

[HTML][HTML] Vertebral osteomyelitis

A Graeber, ND Cecava - 2018 - europepmc.org
Objectives: Identify the patient population at risk for vertebral osteomyelitis. Describe the
clinical evaluation of vertebral osteomyelitis. Review typical imaging findings in vertebral …

[HTML][HTML] A scoring system for the preoperative evaluation of prognosis in spinal infection: the MSI-20 score

S Lener, C Wipplinger, A Lang, S Hartmann… - The Spine Journal, 2022 - Elsevier
Abstract BACKGROUND CONTEXT Spinal infection (SI) is a life-threatening condition and
its treatment remains challenging. Recent studies have supported early and aggressive …

Vertebral osteomyelitis: a mortality analysis comparing surgical and conservative management

S Zadran, PH Pedersen, S Eiskjær - Global Spine Journal, 2020 - journals.sagepub.com
Study Design: Retrospective cohort study. Objectives: To compare the mortality between
patients treated for vertebral osteomyelitis (VO) with either surgical or conservative …

[HTML][HTML] Early surgery may lower mortality in patients suffering from severe spinal infection

S Lener, C Wipplinger, A Stocsits, S Hartmann… - Acta …, 2020 - Springer
Purpose Spinal infection (SI) is a life-threatening condition and treatment remains
challenging. Numerous factors influence the outcome of SI and both conservative and …

Management of vertebral osteomyelitis in adults

WJ Kim, C Park, K Sarraf - British Journal of Hospital …, 2023 - magonlinelibrary.com
Vertebral osteomyelitis is a condition that predominantly affects older men with chronic
comorbidities, such as diabetes, renal and hepatic failure, or immunosuppression …

[HTML][HTML] Beta-lactam–resistant Staphylococcus aureus in spinal osteomyelitis and spondylodiscitis: current landscape in antibiotic resistance, treatment, and …

RS Berreta, H Zhang, D Alsoof, CL McDonald… - … of Neurosurgery: Spine, 2023 - thejns.org
OBJECTIVE Spinal osteomyelitis and spondylodiscitis (SD) are infections of the vertebral
body and disc, respectively, with more than 50% associated with Staphylococcus aureus …