Background Our goal is to optimize stem cell-based tissue engineering strategies in the
context of the intervertebral disc environment. We explored the benefits of co-culturing …

Study Design. This study explores the use of bilaminar coculture pellets of mesenchymal
stem cells (MSCs) and nucleus pulposus cells (NPCs) as a cell-based therapy for …

BACKGROUND CONTEXT: Harnessing the potential of stem cells is an important strategy
for regenerative medicine. This study explores the use of bilaminar coculture pellets (BCPs) …

BACKGROUND CONTEXT: Different strategies to supplement/replenish the disc cell
population have been proposed. Recently, adult stem cells have shown promise as a cell …

Purpose: During in vivo stem cell differentiation, mature cells often induce the differentiation
of nearby stem cells. Accordingly, prior studies indicate that a randomly mixed coculture can …

Study Design. After plating for 6 passages on either plastic flasks or extracellular matrix
(ECM) deposited by synovium-derived stem cells (SDSCs), expanded nucleus pulposus …

Object The object of this study was to characterize the regenerative potential of cells isolated
from herniated disc tissue obtained during microdiscectomy. The acquired data could help to …

Purpose There is increasing interest in the development of cell therapy as a possible
approach for the treatment of degenerative disc disease. To regenerate nucleus pulposus …

Aims: While mesenchymal stem cell (MSC)-based therapies for repair of the degenerate
intervertebral disc (IVD) have been proposed, the interaction of MSCs with cells of the …

Purpose Bone marrow stromal cells (BMSCs) have been proposed to complement the
declining population of nucleus pulposus cells (NPCs) found in a degenerative …