Intra-medullary Tuberculomas: Case Series ========================================= * N. Pradeep * Raviraj Ghorpade * Ravishankar Naik * Prakash R Malur ## Abstract Intramedullary spinal tuberculoma is an extremely rare disease when compared to pulmonary, extrapulmonary and skeletal tuberculosis in developing countries. In the absence of systemic tuberculosis, clinical presentation is non distinctive from other intramedullary lesions. We report two cases of intramedullary tuberculoma both presenting with signs and symptoms of space occupying lesions. Surgical excision was done in both cases following which patients improved neurologically. Histopathological evaluation is essential to provide curative treatment. * intramedullary * tuberculoma * spinal ## Introduction Intramedullary tuberculoma is a rare cause of Spinal cord compression. Intradural spinal tuberculosis is rare while Intramedullary spinal tuberculomas (IMT) are still rare;1 the incidence quoted is two in 100,000 cases of all tuberculosis.2 Intramedullary spinal TB was first described by Abercrombie in 1828.3 Spinal intramedullary tuberculous abscesses (ITA) is still rare.4We report two cases of intramedullary spinal tuberculoma. ## Case Report 1 A 55-year-old man presented with asymmetric onset of paraparesis since five months. Initially he noticed weakness in the left foot since five months, followed by right foot since three months. Later, slowly progressing to proximal muscles. He noticed tingling and numbness in the left foot for 3 months which gradually ascended proximally. He had urinary urgency since two months. History of significant weight loss and loss of appetite since five months. No history suggestive of stiffness, involuntary movements, flexor spasm, thinning of muscles. Past history of tuberculosis, diabetes mellitus was absent. On examination patient was conscious, oriented. Higher mental functions and cranial nerves appeared normal. On inspection of spine and cranium was normal. He had mild atrophy of left leg and foot muscles. He had asymmetrical paraparesis (right: proximal 4+/5, distal 4/5; left: proximal 4/5, distal 3/5). Sensation below L3 level was impaired. Deep tendon reflexes normal in upper limb and sluggish in lower limb. Right side plantar response was extensor and left side was flexor. Cremasteric reflex was absent. Routine blood investigations was normal. Chest Xray was normal. MRI of spine plain and contrast revealed intramedullary peripherally hypointense lesion with central hyperintensity and perilesional edema at D12-L1 level on T2 W images with intense peripheral enhancement on gadolinium injection (Target sign) (Figure 1). ![Fig. 1](http://ijssurgery.com//https://www.ijssurgery.com/content/ijss/11/1/2/F1.medium.gif) [Fig. 1](http://ijssurgery.com//content/11/1/2/F1) Fig. 1 Peripherally ring enhancing thick walled lesion with perilesional edema(target sign). ## Case Report 2 A twenty-three-year-old woman presented with asymmetrical weakness of left upper and lower limbs since two months. She noticed tingling and numbness of left upper and lower limbs since three months. Initially she noticed weakness in the left hand and left foot which gradually ascended proximally. No history suggestive of limb stiffness, involuntary movements, flexor spasm, bowel and bladder disturbances. She was diagnosed with pulmonary tuberculosis with tubercular cervical lymphadenopathy and cold abscess two years back. She had completed her antitubercular treatment course following diagnosis. On examination patient was conscious and oriented. Higher mental functions and cranial nerves were normal. Inspection of cranium and spine was normal. She had asymmetrical weakness of upper limbs (right: proximal and distal 5/5; left: proximal 4/5, distal 3/5) lower limb (right: proximal and distal 5/5; left: proximal and distal 4/5). Upper limb and lower limb reflexes were exaggerated with left plantar extensor and right flexor. Sensation on left side below C5 level was decreased. Rest of the systemic examination was normal. Routine blood investigation and chest x-ray was normal. Magnetic resonance imaging spine revealed intramedullary lesion at C4, 5 level which was hypointense on T2 W images and isointense on T1. Perilesional edema was present. On contrast, there was ring enhancement with central hypointensity (Figure 2). ![Fig. 2](http://ijssurgery.com//https://www.ijssurgery.com/content/ijss/11/1/2/F2.medium.gif) [Fig. 2](http://ijssurgery.com//content/11/1/2/F2) Fig. 2 (a) Hypointense with well-defined borders on T2 W, (b) images enhancing intensely on contrast injection with central hypointensity. Both patients were started on antitubercular and antiedema drugs. Both underwent laminectomy with midline durotomy and myelotomy with total excision of lesion. Post-operative recovery was uneventful. In both cases tuberculoma was confirmed on histopathology (Figure 3). Anti-tubercular treatment was continued. Post op follow up of case one with 18 months showed near normal lower limb power and normal sphincter functions. Case two follow up of six months showed good improvement in left extremities motor power with mild tingling numbness of left upper limb. ![Fig. 3](http://ijssurgery.com//https://www.ijssurgery.com/content/ijss/11/1/2/F3.medium.gif) [Fig. 3](http://ijssurgery.com//content/11/1/2/F3) Fig. 3 HPR. 10x shows caseating granulomatous lesion and showing giant cell granuloma on 40x. ## Discussion Spinal intramedullary tuberculoma is a rare disease; its incidence among patients with tuberculosis is only two per 100,000 accounting for only two percent of all cases of central nervous system tuberculosis. The ratio of intramedullary tuberculoma to intracerebral tuberculoma is approximately 1:42 and 72% of lesions are located in the thoracic cord.4 Case one had dorsolumbar junction tuberculoma with no pulmonary disease. Spinal intramedullary tuberculoma is mostly induced by hematogenous dissemination or cerebrospinal fluid infection. Tuberculomas develop following haematogenous dissemination of bacilli from an infection elsewhere in the body, usually lung. Case two had pulmonary tuberculosis for which she had completed her antitubercular course and had cervical tuberculoma which is rare location. There is a slight male preponderance for intramedullary spinal cord tuberculoma (M:F, 1.5:1). Duration of symptoms at presentation varies from three to twenty months (mean 11.5 months).5 Chest radiographs and CT scanning are effective measures for the detection of pulmonary tuberculosis and extrapulmonary tuberculosis. For spinal intramedullary tuberculosis, MRI is the optimal measure because it can accurately show location, size, and number of lesions, as well as whether there is degeneration and necrosis around the lesions. In the early phase, the tuberculoma is characterized by severe infective reactions, poor formation of the gel capsule and severe edema around the lesion. During this phase, both T1W and T2W images show equal signal intensity and they are evenly enhanced after being intensified. As the gel content in the tuberculoma increases, the peripheral edema is alleviated or may disappear. As a result, T1W images show equal signal intensity; meanwhile, T2W shows equal or low signal intensity. After enhanced scanning, there is rim enhancement and low signal in the central region. With the development of caseation, T2W images show a typical “target sign”6, 7 which means that it exhibits a range from the low signal target to the high signal rim and also from the center of the low signal rim to the peripheral parts. Differential diagnoses include common spinal intramedullary tumors, such as astrocytic glioma, ependymoma, and hemangioblastoma. Preoperative antituberculous therapy for 1–2 weeks may avoid spreading of intraoperative tuberculosis. Careful dissection and resection could get good recovery for intramedullary tuberculoma with mass effect and paradoxical enlargement of the tuberculoma at late stage.8, 9 Postoperative whole course antituberculous chemotherapy is mandatory. ## Conclusion Though spinal intramedullary tuberculomas are rare. It should be considered in the differential diagnosis of intramedullary lesions in developing countries. Timely intervention with surgery and chemotherapy yields good prognosis. ## Disclosures & COI The authors report no relevant disclosures. * Copyright © 2017 ISASS - This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery ## References 1. Rhoton EL, Ballinger WE, Quisling R, Sypert GW (1988) Intramedullary spinal tuberculoma. Neurosurgery 22:733–6. 2. Nussbaum ES, Rockswold GL, Bergman TA, Erickson DL, Seljeskog EL (1995) Spinal tuberculosis: A diagnostic and management challenge. J Neurosurg 83:243–7. 3. 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