Abstract
Background Minimally invasive spine surgery, particularly lateral lumbar interbody fusion, offers advantages over open surgery, including reduced blood loss and shorter hospital stays. The prone lateral lumbar interbody fusion (PL-LIF) is an evolution of lateral lumbar interbody fusion that enables posterior instrumentation without repositioning, enhances sagittal correction, and may improve operative efficiency. However, concerns remain regarding prolonged psoas retraction and increased radiation exposure. While instrument tracking technologies have improved workflow and reduced radiation in other minimally invasive surgeries, such as minimally invasive transforaminal lumbar interbody fusion, their role in PL-LIF remains unstudied. This study evaluates the impact of instrument tracking on psoas retraction time, radiation exposure, and procedural efficiency in PL-LIF.
Methods A retrospective analysis reviewed PL-LIF procedures using instrument tracking technology at a single institution over 7 months. Operative times (minutes), radiation exposure (mGy and number of x-ray images), and patient-reported outcome measures (PROMs) were analyzed. The dataset was divided into temporal quartiles based on the chronological order of surgical cases to evaluate the impact of learning over time. PROMs were also reported.
Results A total of 52 consecutive PL-LIF levels across 39 patients were included. The surgeon had 2 years of PL-LIF experience but had no prior experience with instrument tracking before the first case in the dataset. Median retractor time across the entire study was 17.43 minutes (interquartile range [IQR]: 7.48). From first to final quartile, the median retractor time consistently decreased from 20.9 to 14.7 minutes (−30%, P = 0.028). Comparing the first and the fourth quartile, the frequency of retractor times less than the 20-minute threshold increased from 46% to 85% (χ² = 4.25, P = 0.04). Median radiation exposure per level was 7.55 mGy (IQR: 4.40), corresponding to 13 x-rays images taken (IQR: 7). Linear regression revealed significant decreases in retractor time in the third (−8.95 minutes, P < 0.001) and final quartiles (−7.55 minutes, P < 0.001). Patient-reported outcome measures improved from baseline to 6 and 12 months, with Oswestry Disability Index decreasing 14.6 and 18.6 points, Veterans RAND 12-Item Physical Component Summary increasing 10.0 and 13.1 points, and Zurich Claudication Questionnaire Symptom Severity and Physical Function decreasing 20.1 to 25.8 and 19.7 to 25.5 points, respectively. All changes exceeded established minimal clinically important differences (all P < 0.001).
Conclusions Prolonged retractor times and substantial radiation associated with the PL-LIF can be dramatically reduced with instrument tracking. Intraoperative radiation exposure was significantly reduced compared with previous studies, with a minimal number of x-rays images required from study onset. Psoas retraction time significantly decreased after an inflection point at 15 cases, ultimately falling below 15 minutes and correlating with adherence to the recommended 20-minute threshold in 85% of cases during the final quartile. Instrument tracking can substantially decrease retractor time and radiation exposure in PL-LIF.
Clinical Relevance Instrument tracking in PL-LIF improves efficiency and safety, reducing psoas retraction time and radiation while maintaining 12-month PROM gains.
Level of Evidence 5.
Introduction
Minimally invasive spine surgery has emerged as a cornerstone of modern spinal procedures for treating degenerative spine disease,1 offering notable advantages including reduced blood loss and shorter hospital stays compared with traditional open spine surgery.1–8 Among these techniques, lateral lumbar interbody fusion (LLIF) stands out as a leading approach for addressing lumbar spine pathology. By utilizing a retroperitoneal, transpsoas corridor, LLIF enables anterior column reconstruction with indirect decompression while obviating the need to traverse the midline stabilizing posterior elements.
The prone lateral lumbar interbody fusion (PL-LIF) technique represents a contemporary evolution of LLIF, combining standard lateral transpsoas access with the biomechanical and logistical advantages of the prone position. Unlike conventional lateral decubitus LLIF, which requires subsequent patient flipping or table rotation for posterior fixation, PL-LIF performs the transpsoas approach with the patient already prone, thereby eliminating the need for repositioning for posterior instrumentation placement, facilitating lordotic correction through gravity, and streamlining operating room workflow.4 In addition, prone positioning may decrease the risk of neural complications as compared with lateral decubitus positioning, as the gravitational pull on the psoas muscle causes the lumbar plexus to shift posteriorly, reducing the need for psoas retraction and resulting in a more predictable course of the neural elements away from the surgical corridor.5 A recent meta-analysis comparing PL-LIF with traditional lateral decubitus LLIF also reported reduced operative time and hospital length of stay.9 Collectively, these characteristics have driven interest in PL-LIF as a potentially more efficient single-position strategy. Conversely, the same study reflects an increase in retractor time, an increase in radiation exposure, and a substantial increase in both sensory and motor complications compared with the more traditional approach. One drawback to PL-LIF compared with traditional lateral interbody fusion has been the increased radiation, which is partially due to the difficult ergonomics of obtaining lateral fluoroscopic images with patient prone.7
Historically, it was recommended that surgeons limit psoas muscle retraction to under 20 minutes to minimize the risk of nerve injury,2 as prolonged retraction was associated with lumbar plexus compromise. Additionally, emerging literature suggests that minimally invasive approaches like PL-LIF are associated with significantly increased fluoroscopic radiation exposure for both patients and operating room staff.6 These findings emphasize the importance of optimizing operative efficiency and workflow while also addressing radiation-related risks for the PL-LIF technique as it gains broader clinical traction.
Instrument guidance and tracking solutions used in contemporary spine surgery span several platforms, including camera-based optical navigation systems and robotics that localize instruments relative to a patient reference frame using reflective markers tracked by infrared cameras,10 electromagnetic tracking systems that can localize compatible instruments without requiring continuous optical line of sight,11 and fluoroscopy-based instrument tracking tools that use calibrated C-arm images plus instrument-attached markers to provide continuous instrument localization between discrete fluoroscopic acquisitions.12 In this study, the surgeon selected TrackX (Hillsborough, NC), a fluoroscopy-based tracking platform, because it integrates into standard C-arm workflows with minimal added operating room footprint and without the need for a separate navigation tower or invasive patient reference fixation, which is particularly practical in single-position lateral workflows where ergonomics and repeated fluoroscopic checks can increase radiation burden and disrupt efficiency. While TrackX has been evaluated in other minimally invasive lumbar fusion settings,3 its application in PL-LIF has not been formally studied, representing a gap in the literature and an opportunity to optimize workflow and mitigate radiation-related risk.
Methods
Patient Selection
At a single institution, consecutive adult patients who underwent minimally invasive PL-LIF by a single surgeon between January 2024 and July 2024 were retrospectively enrolled. All procedures were performed using a fluoroscopy-based instrument tracking system (TrackX). Patients with a high iliac crest that required the use of angled disc prep instrumentation were excluded from the study. All other patients were included in the analysis.
Surgical Technique
The surgical technique for PL-LIF was performed in accordance with the approach previously described by Smith et al,8 utilizing a transpsoas lateral access in the prone position with posterior instrumentation placed without intraoperative repositioning. All procedures were performed under neuromonitoring and fluoroscopic guidance. The instrument tracking software display is depicted in Figure 1.
Instrument-tracking software display showing simultaneous lateral and anteroposterior fluoroscopic views during lateral lumbar interbody fusion. (A) Initial dilator tracked and docked near the mid-disc. (B) Anterior retractor blade tracking after lateral confirmation and anatomic reregistration, with blade opening to the anterior disc border and safe AP docking over the disc space. (C) Tracked trial after repeat AP/lateral confirmation and reregistration, demonstrating advancement across the disc space with orthogonal alignment on the lateral view. (D) Final AP and lateral fluoroscopy confirming implant position.
Data Collection
Outcome measures were recorded per spinal level and included psoas retractor time (minutes), intraoperative radiation exposure (mGy), and the total number of x-ray images acquired. Data were extracted from intraoperative video recordings and fluoroscopic imaging logs generated by the tracking software. Retractor time was measured as the duration between initial retractor deployment on the disc space and its removal based on either video frame timestamps or fluoroscopic image sequences when video was unavailable. Retractor radiation was defined as the difference in cumulative radiation dose between the last x-ray image prior to retractor deployment and the final x-ray image in which the retractor was still present. The total number of x-ray images per level was manually counted from the fluoroscopic image series. Additionally, we summarized baseline patient-reported outcome measures, evaluated change from baseline at 6 and 12 months, compared distributions across time, and defined minimal clinically important difference (MCID) responders using thresholds of 15 for Oswestry Disability Index (ODI),13 5 for VR-12 PCS,14 and 1 point for ZCQ Symptom Severity and Physical Function.15
Statistical Analysis
Cases were stratified into 4 chronological quartiles to assess temporal trends. For each quartile, we calculated descriptive statistics (median and interquartile range [IQR]) for continuous variables. Continuous outcomes were compared across quartiles using Kruskal-Wallis tests, categorical outcomes were compared using χ 2 tests, and linear regression was employed to model the association between quartile and key intraoperative metrics. Statistical significance was defined as 2‐tailed P < 0.05.
Results
Case Volume and Level Distribution
A total of 52 consecutive PL-LIF lumbar motion segments were analyzed across 39 patients. The cohort mean age was 69.1 ± 7.3 years; 69.2% of patients were women, and 30.8% of patients were men. Most patients were white (94.9%) and non-Hispanic (76.9%). Mean body mass index was 31.9 ± 5.6 kg/m². Single-level constructs predominated (27; 69.2%), with 2-level (10; 25.6%) and 3-level (2; 5.1%) fusions comprising the remainder. L4 to L5 was the most frequently treated segment (23; 44.2%), followed by L3 to L4 (19; 36.5%), L2 to L3 (8; 15.4%), and L1 to L2 (2; 3.8%). Most patients were nonsmokers (61.5%), 35.9% were former smokers, and 2.6% were current smokers. Hypertension (56.4%) and diabetes (20.5%) were the most common comorbidities, with asthma/chronic obstructive pulmonary disease each present in 12.8% of patients and chronic kidney disease in 5.1%. The 52 segments were divided chronologically into 4 equal quartiles of 13 segments each based on case order (Table 1).
Study participant characteristics (N = 39).
Operative and Outcome Metrics
Across all 39 patients, the median skin-to-skin operative time was 20.45 minutes (IQR: 9.05), the median radiation dose was 8.43 mGy (IQR: 6.04), and the median number of fluoroscopic images was 14 (IQR: 8; Table 1). Across operative levels, median psoas retractor time was 17.43 minutes (IQR: 7.48), and median retractor radiation exposure was 7.55 mGy (IQR: 4.40). When operative levels were stratified chronologically by quartile, psoas retractor time was 20.90 minutes (IQR: 6.34) in the first quartile, 18.50 minutes (IQR: 5.83) in the second quartile, 16.39 minutes (IQR: 5.35) in the third quartile, and 14.74 minutes (IQR: 3.34) in the fourth quartile (Figure 1A and B). Median retractor radiation exposure was 6.24 mGy (IQR: 2.86) in the first quartile, 8.01 mGy (IQR: 4.76) in the second quartile, 10.96 mGy (IQR: 10.84) in the third quartile, and 8.89 mGy (IQR: 3.32) in the fourth quartile (Figure 1C and D). Across all cases, the median total x-ray image count was 13 (IQR: 7). By quartile, the median x-ray image count was 9 (IQR: 9.00) in the first quartile, 11 (IQR: 5.00) in the second quartile, 18 (IQR: 12.00) in the third quartile, and 13 (IQR: 5.00) in the fourth quartile (Table 2).
(A) Scatter plot with linear fit depicting psoas retractor time (minutes) vs sequential prone lateral lumbar interbody fusion (PL-LIF) levels. (B) Kernel density plot of retractor time stratified by quartile. (C) Scatter plot with linear fit depicting retractor radiation exposure (mGy) vs sequential PL-LIF. (D) Kernel density plot of retractor radiation exposure (mGy) stratified by quartile.
Retractor time (minutes), retractor radiation (mGy), and x-ray image count across all PL-LIF levels.
Patient-reported outcomes improved from baseline to 6 and 12 months. ODI fell by 14.6 and 18.6 points from a baseline of 42.2 ± 14.45; VR-12 PCS rose by 10.0 and 13.1 from 27.9 ± 9.03; ZCQ Symptom Severity decreased by 20.1 and 25.8 from 68.4 ± 13.62; and ZCQ Physical Function decreased by 19.7 and 25.5 from 66.3 ± 11.83. Repeated measures analysis of variance tests across time points were significant (P < 0.001) for all measures (Table 3). Using MCIDs of 15 for ODI, 5 for VR-12 PCS, and 1 for both ZCQ Symptom Severity and ZCQ Physical Function, all observed changes at 6 and 12 months exceeded these thresholds (Figure 3). There was no difference when analyzing patient outcomes across quartiles.
Patient-reported outcomes at baseline, with change from baseline to 6 mo and 12 mo, respectively.
Estimated marginal means of psoas retractor time (minutes) by quartile from the linear regression model with 95% confidence intervals.
Statistical Comparisons Across Quartiles
A Kruskal-Wallis test demonstrated a statistically significant difference in retractor time across quartiles (H = 9.77, df = 3, P = 0.021). Post hoc pairwise comparisons using the Dwass-Steel-Critchlow-Fligner method revealed a significant difference between the first and fourth quartiles (W = −3.736, P = 0.041), with no other comparisons reaching statistical significance. There was no statistically significant difference in retractor radiation exposure across quartiles (H = 6.19, df = 3, P = 0.103). A significant difference in total x-ray image count was observed across quartiles (H = 9.84, df = 3, P = 0.020); however, none of the pairwise comparisons reached statistical significance. Operative levels with total retractor time under 20 minutes increased from 6 of 13 cases in the first quartile (46%) to 11 of 13 in the fourth quartile (85%). This increase was statistically significant (χ²[1] = 4.25, P = 0.039, N = 26), reflecting a pronounced shift toward shorter retractor times by the fourth quartile.
Regression Modeling
Linear regression was used to evaluate the association between case quartile, total x-ray image count, and psoas retractor time. The model demonstrated a moderately strong fit (R = 0.675, R² = 0.456; N = 52). Compared with first-quartile cases, retractor time was 3.26 minutes shorter in the second quartile (β = −3.264, 95% CI: −7.31 to 0.78, P = 0.111), 8.95 minutes shorter in the third quartile (β = −8.954, 95% CI: −13.18 to −4.73, P < 0.001), and 7.55 minutes shorter in the fourth quartile (β = −7.548, 95% CI: −11.60 to −3.50, P < 0.001), indicating a significant reduction in retractor duration with procedural experience (Figure 4). Total x-ray image count was independently associated with increased retractor time, with each additional x-ray image corresponding to a 0.387-minute increase (95% CI: 0.230–0.544, P < 0.001). The intercept of 17.95 minutes (95% CI: 14.44–21.46, P < 0.001) reflects the expected retractor time for a first-quartile case in which no x-rays images were obtained. Collinearity diagnostics indicated negligible variance inflation factors (1.02–1.06), supporting the independence of quartile and x-ray image count effects.
Mean patient-reported outcome measure trajectories with points as means and 95% CIs, and the dashed line marks the MCIDs: (A) ODI, MCID: 15; (B) VR-12 PCS, MCID: 5; (C) ZCQ Symptom Severity, MCID: 1; and (D) ZCQ Physical Function, MCID: 1. MCID, minimal clinically important difference; ODI, Oswestry Disability Index; ZCQ, Zurich Claudication Questionnaire.
Discussion
Context and Persistent Challenges of the PL-LIF
PL-LIF aims to improve traditional lateral interbody fusion by pairing transpsoas access with the biomechanical and logistical advantages of prone positioning.4 Unlike lateral decubitus LLIF, which typically requires subsequent patient repositioning or table rotation to accomplish posterior fixation, PL-LIF undertakes the transpsoas exposure with the patient already prone, thereby permitting single-position posterior instrumentation and gravity-facilitated lordotic correction.9 Despite these potential improvements, adoption of PL-LIF remains tempered by 2 enduring intraoperative concerns: the need for prolonged psoas retraction and the subsequent risk for lumbar plexus injury and elevated radiation exposure to patients and operating room personnel.2,6 To reduce neural injury rates, earlier lateral surgical practices emphasized limiting cumulative psoas retraction time to less than 20 minutes.2
Interestingly, a new emerging study suggests that retractor duration may reflect anatomic difficulty and surgeon efficiency rather than an independent causal driver of plexus injury. In this retrospective cohort study of 658 patients, the authors evaluated the applicability of the “20-minute rule” during LLIF and found no significant difference in retractor time between patients with postoperative nerve injury (19.6 ± 11.2 minutes) and those without (17.5 ± 8.0 minutes). They found that the 20-minute threshold demonstrated poor predictive value (sensitivity 50%, specificity 73.8%, and positive predictive value 3.4%). The authors concluded that strict adherence to the 20-minute rule does not prevent nerve injury and recommend prioritizing safe, deliberate techniques over speed. However, despite the study’s retrospective nature and limited data collection, the trend toward longer retractor times in patients with nerve injury (bordering the 20-minute threshold) raises concern for time-dependent neural risk, particularly given the study’s low event rate and limited power to detect small but clinically meaningful differences. The truth is likely multifactorial. Retractor time may contribute to injury risk, but so may other variables such as anatomy, retractor placement, and neuromonitoring response. Regardless of root cause, this study clearly shows a greater than 4-fold increase as retractor time increases, with no clear increase until after the 20-minute mark is exceeded. Given this biological plausibility and the historical use of the 20-minute cutoff as a safety guideline, we elected to retain it as a practical benchmark for evaluating surgical efficiency and minimizing traction-related complications.
Concurrently, minimally invasive approaches often incur higher cumulative fluoroscopic exposure than compared with open techniques due to the need for intraoperative localization, anatomical visualization, and instrument navigation with associated long-term risk for radiation-related complications.6,16,17 In operative workflows, an effective adjunct should streamline the surgical approach while maintaining—and ideally enhancing—safety. Our aim was strictly exploratory: to examine whether instrument tracking using TrackX is associated with operative efficiency (decreased psoas retractor time) and improved radiation stewardship (x-ray image count and radiation exposure) in PL-LIF.
Instrument Tracking, Efficiency, and Radiation
Fluoroscopy-based instrument tracking provides continuous spatial context and rapid anatomical remapping after soft tissue shift.18 In this series, the use of instrument-tracking software during prone lateral interbody fusion was associated with a median radiation exposure of 8.43 mGy (IQR 6.04) and a median of 14 fluoroscopic images (IQR 8) across 39 patients. Additionally, psoas retractor time decreased across the operative timeline, while x-ray image count and per-level radiation dose remained low. These values are markedly lower than those reported in prior series without such software, including Striano et al19 (108.6 ± 16.9 mGy for single-level LLIF/extreme lateral interbody fusion [XLIF]) and Godzik et al20 (171 ± 60th mGy in a prone lateral cadaveric model). Similarly, Lamartina and Berjano’s Pro-XLIF study7 reported mean fluoroscopic use of 151.4 ± 99.8 shots (adjusted mean 108 shots) compared with 108.3 ± 56.7 shots (adjusted mean 91) for standard XLIF. Compared with previously published series, our cohort showed low radiation exposure and fluoroscopic image counts. These findings compare favorably with the existing literature, but because the comparison is historical and indirect, they should not be interpreted as establishing a definitive reduction caused by instrument tracking.
In addition, procedure speed improved with operative experience without an associated increase in total x-ray image number per case, in contrast with the usual pattern, where adopting a new technology may manifest as higher radiation exposure before decreasing and leveling off.21 Findings parallel prior minimally invasive transforaminal lumbar interbody fusion reports demonstrating reduced operative time and radiation with tracking technologies3,22,23 while extending generalizability to PL-LIF, a procedure with distinct corridor geometry and ergonomic constraints. We also observed improvement in patient-reported outcomes through 12 months, supporting maintained clinical efficacy with the addition of instrument tracking. Mean improvements exceeded MCIDs for all measures, which supports that patients experienced pragmatic improvements in daily function, not only statistical shifts. The pattern is consistent with early recovery by 6 months and continued, with smaller gains by 12 months, which matches typical trajectories for lumbar surgery. VR-12 PCS captured global physical health improvement, while ODI and ZCQ domains reflected condition-specific relief and better function, providing convergent validity across measures.
Taken together, these comparisons suggest that software-assisted instrument tracking was associated with low radiation dose and reduced fluoroscopy demand in prone lateral approaches relative to previously described techniques. In addition to lowering exposure, instrument tracking could help standardize workflow and decrease reliance on continuous fluoroscopy, with potential implications for procedural safety, although these benefits warrant confirmation in larger prospective studies.
Mechanisms and Alternative Explanations
Operative efficiency likely reflects convergent mechanisms: uninterrupted visualization reduces microdelays in reconstructing 3-dimensional orientation24; reduced task switching lowers cognitive load25; rapid remapping diminishes navigation downtime18; accumulating trust in positional fidelity lessens reliance on confirmatory fluoroscopy12; and ergonomic conservation through fewer axial and cervical rotations sustains fine motor precision later in the case. Furthermore, integrating neuromonitoring in both lateral and prone-lateral approaches is essential, providing real-time physiological feedback that markedly reduces unnecessary fluoroscopy and greatly enhances confidence in maintaining a safe surgical corridor.2,26 Alternative explanations include chronological learning, Hawthorne effect, and complexity drift. However, the absence of early elevated imaging argues against a purely chronological effect, and a Hawthorne effect would likely attenuate rather than stabilize. While the drift toward simpler cases could reduce retraction time, stable radiation uses, and imaging counts suggest minimal selection bias. Residual confounding remains possible and warrants controlled validation.
Clinical, Safety, and Implementation Implications
Shorter retraction intervals may reduce lumbar plexus irritation risk,6,26 while sustained low radiation exposure mitigates cumulative occupational and patient risk.16,17 When layered upon established minimally invasive benefits of lower blood loss, reduced tissue disruption, shorter hospitalization, and lower opioid requirements,27 instrument tracking functions as a force multiplier. Continuous localization may directly support high-quality neuromonitoring by correlating instrument trajectory with evolving signals and enabling earlier recognition of subtle corridor shifts.2,26,28 Time-stamped positional data and synchronized neuromonitoring streams could seed predictive analytics for adaptive retraction intervals and surgical tray optimization. Implementation considerations include potential offsets of capital cost through shorter operative duration, fewer radiation-associated confirmation shots, and reduced shielding wear. Ergonomic benefits (reduced head turns and fewer search actions) may decrease fatigue and musculoskeletal strain, factors relevant to surgeon longevity yet underreported. Selective deployment may yield the greatest marginal benefit in patients with high iliac crest, variant psoas morphology, obesity, prior retroperitoneal surgery, or multilevel constructs, while straightforward single-level cases may see narrower incremental gain.
Limitations and Future Directions
Limitations include modest sample size (39 patients, 52 levels), retrospective data collection, and a single-surgeon, single-center design. The primary shortcoming is the absence of a contemporaneous nontracking control group, which precludes direct comparison of operative timing, clinical outcomes, and radiation exposure and limits causal attribution of observed findings to instrument tracking. The cohort was predominantly white and non-Hispanic, which may further limit generalizability to more diverse populations and practice settings. Potential confounders (body mass index, psoas morphology, deformity parameters, and prior surgery) were not stratified. Anatomic complexity factors, including iliac crest height, psoas size and morphology, and deformity severity, were not stratified. Although only one patient was excluded due to the need for angled instrumentation, and all remaining cases were included in chronological order during the study period without additional exclusions, the results may nevertheless be biased toward less complex anatomy and may underestimate psoas retraction time and radiation utilization, limiting generalizability to higher-complexity cases. Radiation metrics were derived from system-reported output rather than patient organ-specific dosimetry. Future work should employ multicenter prospective or randomized study designs with appropriate comparators, incorporate anatomic and patient-reported outcomes, perform time-driven activity-based cost analysis, include ergonomic and fatigue assessments, and utilize high-resolution positional plus neuromonitoring logs for predictive modeling of escalation or impending threshold breaches in retraction duration. Simulation or structured proctorship studies may determine whether formalized training with instrument tracking technology further compresses early efficiency curves. Integration with adaptive dose modulation and machine learning-driven alerting warrants exploration.
Conclusions
Fluoroscopy-based instrument tracking in PL-LIF reduced psoas retractor time, maintained very low radiation exposure, and standardized workflow without increasing imaging demand and affecting patient outcomes. Benefits appeared early and persisted, indicating both immediate and scalable impact. Findings extend previously reported efficiency and safety signals from other minimally invasive lumbar procedures to the prone lateral paradigm and address long-standing concerns regarding neural protection and radiation burden. Evidence of behavior modulation independent of image volume positions tracking as an active catalyst for safer surgical conduct. Routine integration has the potential to elevate procedural safety, accelerate proficiency acquisition, and support broader adoption of PL-LIF. Larger controlled studies with longitudinal clinical, functional, and economic endpoints are needed to confirm durability, refine patient selection criteria, and define best practice implementation pathways.
Footnotes
Funding The authors received no financial support for the research, authorship, and/or publication of this article.
Disclosures and Conflicts of Interest M.M.A. is a consultant for TrackX. J.I. has stock options with TrackX.
- This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2026 ISASS. To see more or order reprints or permissions, see http://ijssurgery.com.
References
- 1.↵Pokorny G , Amaral R , Marcelino F , et al . Minimally invasive versus open surgery for degenerative lumbar pathologies:a systematic review and meta-analysis. Eur Spine J. 2022;31(10):2502–2526. 10.1007/s00586-022-07327-3
- 2.↵Bendersky M , Solá C , Muntadas J , et al . Monitoring lumbar plexus integrity in extreme lateral transpsoas approaches to the lumbar spine: a new protocol with anatomical bases. Eur Spine J. 2015;24(5):1051–1057. 10.1007/s00586-015-3801-9
- 3.↵Hamouda F , Wang TY , Gabr M , et al . A prospective comparison of the effects of instrument tracking on time and radiation during minimally invasive lumbar interbody fusion. World Neurosurg. 2021;152:e101–e111. 10.1016/j.wneu.2021.05.058
- 4.↵Drossopoulos PN , Bardeesi A , Wang TY , et al . Advancing prone-transpsoas spine surgery: a narrative review and evolution of indications with representative cases. J Clin Med. 2024;13(4):1112. 10.3390/jcm13041112
- 5.↵Gandhi SV , Dugan R , Farber SH , Godzik J , Alhilali L , Uribe JS . Anatomical positional changes in the lateral lumbar interbody fusion. Eur Spine J. 2022;31(9):2220–2226. 10.1007/s00586-022-07195-x
- 6.↵Tian NF , Wu YS , Zhang XL , Xu HZ , Chi YL , Mao FM . Minimally invasive versus open transforaminal lumbar interbody fusion: a meta-analysis based on the current evidence. Eur Spine J. 2013;22(8):1741–1749. 10.1007/s00586-013-2747-z
- 7.↵Lamartina C , Berjano P . Prone single-position extreme lateral interbody fusion (pro-XLIF): preliminary results. Eur Spine J. 2020;29(S1):6–13. 10.1007/s00586-020-06303-z
- 8.↵Pimenta L , Taylor WR , Stone LE , Wali AR , Santiago-Dieppa DR . Prone transpsoas technique for simultaneous single-position access to the anterior and posterior lumbar spine. Operative Surg. 2021;20(1):E5–E12. 10.1093/ons/opaa328
- 9.↵Rohde M , Echevarria A , Carrier R , Zinner M , Ngan A , Verma R . Prone single position approach to lateral lumbar interbody fusion: systematic review and meta-analysis. Int J Spine Surg. 2024;18(4):408–417. 10.14444/8626
- 10.↵Wilson JP , Fontenot L , Stewart C , Kumbhare D , Guthikonda B , Hoang S . Image-guided navigation in spine surgery: from historical developments to future perspectives. J Clin Med. 2024;13(7):2036. 10.3390/jcm13072036
- 11.↵Fraser JF , Von Jako R , Carrino JA , Härtl R . Electromagnetic navigation in minimally invasive spine surgery: results of a cadaveric study to evaluate percutaneous pedicle screw insertion. SAS J. 2008;2(1):43–47. 10.1016/SASJ-2007-0105-RR
- 12.↵Wang TY , Hamouda F , Sankey EW , Mehta VA , Yarbrough CK , Abd-El-Barr MM . Computer-assisted instrument navigation versus conventional C-arm fluoroscopy for surgical instrumentation: accuracy, radiation time, and radiation exposure. AJR Am J Roentgenol. 2019;213(3):651–658. 10.2214/AJR.18.20788
- 13.↵Solomito MJ , Kia C , Makanji H . The minimal clinically important difference for the oswestry disability index substantially varies based on calculation method: implications to value-based care. Spine (Phila Pa 1976). 2025;50(10):707–712. 10.1097/BRS.0000000000005074
- 14.↵Lynch CP , Cha EDK , Mohan S , Geoghegan CE , Jadczak CN , Singh K . Two-year validation and minimal clinically important difference of the Veterans RAND 12 Item Health Survey Physical Component Score in patients undergoing minimally invasive transforaminal lumbar interbody fusion. J Neurosurg Spine. 2022;36(5):731–740. 10.3171/2021.6.SPINE21231
- 15.↵Fukushima M , Oka H , Oshima Y , et al . Evaluation of the minimum clinically important differences of the zurich claudication questionnaire in patients with lumbar spinal stenosis. Clin Spine Surg. 2020;33(10):E499–E503. 10.1097/BSD.0000000000000983
- 16.↵Crawford AM , Striano BM , Giberson-Chen CC , et al . Projected lifetime cancer risk associated with intraoperative computed tomography for lumbar spine surgery. Spine (Phila Pa 1976). 2023;48(13):893–900. 10.1097/BRS.0000000000004685
- 17.↵Crawford AM , Striano BM , Lightsey HM , et al . Projected lifetime cancer risk for patients undergoing spine surgery for isthmic spondylolisthesis. Spine J. 2023;23(6):824–831. 10.1016/j.spinee.2023.01.014
- 18.↵Srinivasan ES , Hamouda F , Gnaedinger AG , et al . Instrument tracking for prone lateral surgery. World Neurosurg. 2023;169:42. 10.1016/j.wneu.2022.10.119
- 19.↵Striano BM , Xiong GX , Lightsey HM , et al . Comparison of radiation exposure between anterior, lateral, and posterior interbody fusion techniques and the influence of patient and procedural factors. Spine (Phila Pa 1976). 2021;46(23):1669–1675. 10.1097/BRS.0000000000004247
- 20.↵Godzik J , Ohiorhenuan IE , Xu DS , et al . Single-position prone lateral approach: cadaveric feasibility study and early clinical experience. Neurosurg Focus. 2020;49(3):E15. 10.3171/2020.6.FOCUS20359
- 21.↵Kumar A , Merrill RK , Overley SC , et al . Radiation exposure in minimally invasive transforaminal lumbar interbody fusion: the effect of the learning curve. Int J Spine Surg. 2019;13(1):39–45. 10.14444/6006
- 22.↵Wang TY , Hamouda F , Mehta VA , et al . Effect of instrument navigation on c-arm radiation and time during spinal procedures: a clinical evaluation. Int J Spine Surg. 2020;14(3):375–381. 10.14444/7049
- 23.↵Shahi P , Vaishnav A , Araghi K , et al . Robotics reduces radiation exposure in minimally invasive lumbar fusion compared with navigation. Spine (Phila Pa 1986). 2022;47(18):1279–1286. 10.1097/BRS.0000000000004381
- 24.↵De Jesus Encarnacion Ramirez M , Chmutin G , Nurmukhametov R , et al . Integrating augmented reality in spine surgery: redefining precision with new technologies. Brain Sci. 2024;14(7):645. 10.3390/brainsci14070645
- 25.↵Wang TY , Mehta VA , Sankey EW , Lavoie S , Abd-El-Barr MM , Yarbrough CK . Operative time and learning curve between fluoroscopy-based instrument tracking and robot-assisted instrumentation for patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Clin Neurol Neurosurg. 2021;206:106698. 10.1016/j.clineuro.2021.106698
- 26.↵Uribe JS , Isaacs RE , Youssef JA , et al . Can triggered electromyography monitoring throughout retraction predict postoperative symptomatic neuropraxia after XLIF? Results from a prospective multicenter trial. Eur Spine J. 2015;24(S3):378–385. 10.1007/s00586-015-3871-8
- 27.↵Drossopoulos PN , Sharma A , Ononogbu-Uche FC , et al . Pushing the limits of minimally invasive spine surgery—from preoperative to intraoperative to postoperative management. JCM. 2024;13(8):2410. 10.3390/jcm13082410
- 28.↵Patel A , McDermott MR , Mundis GM , et al . The “20-minute rule” in lateral lumbar interbody fusion. Fact or fiction? A multi-center analysis of 658 patients. Global Spine J. 2025;15(7):3189–3198. 10.1177/21925682251321490










