TY - JOUR T1 - The Inherent Value of Preoperative Optimization—Absolute and Incremental Reduction in Components of Metabolic Syndrome Can Enhance Recovery and Minimize Perioperative Burden JF - International Journal of Spine Surgery JO - Int J Spine Surg SP - 412 LP - 416 DO - 10.14444/8255 VL - 16 IS - 3 AU - Sara Naessig AU - Ashok Para AU - Kevin Moattari AU - Bailey Imbo AU - Tyler K. Williamson AU - Rachel Joujon-Roche AU - Peter Tretiakov AU - Lara Passfall AU - Oscar Krol AU - Nicholas Kummer AU - Waleed Ahmad AU - Katherine Pierce AU - Ethan Ayres AU - Shaleen Vira AU - Bassel Diebo AU - Peter G. Passias Y1 - 2022/06/01 UR - http://ijssurgery.com//content/16/3/412.abstract N2 - Background Metabolic syndrome (MetS) is an amalgamation of medical disorders that ultimately increase patient complications. Factors such as obesity, hypertension, dyslipidemia, and diabetes are associated with this disease complex.Objective To assess the incremental value of improving MetS in relation to clinical outcomes.Study Design Retrospective cohort study.Methods Patients undergoing elective spine surgery were isolated and separated into 2 groups: MetS patients (>2 metabolic variables: hypertension, diabetes, obesity, and triglycerides) and nonmetabolic patients (<2 metabolic variables). T tests and χ 2 tests compared differences in patient demographics. Resolution of metabolic factors was incrementally analyzed for their effect on perioperative complications through utilization of logistic regressions.Results A total of 2,855,517 elective spine patients were included. Of them, 20.1% had MeTS (81.4% two factors, 18.4% three factors, 0.2% four factors). MetS patients were older, less female, and more comorbid (P < 0.001). About 28.8% MetS patients developed more complications such as anemia (9.8% vs 5.9%), device related (3.5% vs 2.9%), neurologic (2.3% vs 1.4%), and bowel issues (9.7% vs 6.8 %; P < 0.05). Controlling for age and procedure invasiveness, having 3 MetS factors increased a patient’s likelihood (0.89×) of developing a perioperative complication (P < 0.05), whereas 2 factors had lower odds (0.82). More specifically, patients who were diabetes, obese, and had hypertension had the greatest odds at developing a complication (0.58 [0.58–0.57]) followed by those who had concomitant hypertension, high triglycerides, and were obese (0.55 [0.63–0.48]; all P < 0.001). MetS patients with 2 factors, being obese and having hypertension produced the lowest odds at developing a complication (0.5 [0.61–0.43]; P < 0.001). These MetS patients also had a lower length of stay than those with 3 and 4 (P < 0.001).Conclusions Metabolic patients improved in perioperative complications incrementally, demonstrating the utility of efforts to mitigate burden of MetS even if not completely abolished.Clinical Relevance This review contributes to the assessment of MetS optimization in the field of adult spine surgery.Level of Evidence 3. ER -