PT  - JOURNAL ARTICLE
AU  - Marc A. Weinstein
AU  - Andrew Beaumont
AU  - Peter Campbell
AU  - Hamid Hassanzadeh
AU  - Vikas Patel
AU  - Amir Vokshoor
AU  - Joshua Wind
AU  - Kristen Radcliff
AU  - Ilyas Aleem
AU  - Domagoj Coric
TI  - Pulsed Electromagnetic Field Stimulation in Lumbar Spine Fusion for Patients With Risk Factors for Pseudarthrosis
AID  - 10.14444/8549
DP  - 2023 Dec 01
TA  - International Journal of Spine Surgery
PG  - 816--823
VI  - 17
IP  - 6
4099  - http://ijssurgery.com//content/17/6/816.short
4100  - http://ijssurgery.com//content/17/6/816.full
SO  - Int J Spine Surg2023 Dec 01; 17
AB  - Background Lumbar spinal fusion surgeries are increasing steadily due to an aging and ever-growing population. Patients undergoing lumbar spinal fusion surgery may present with risk factors that contribute to complications, pseudarthrosis, prolonged pain, and reduced quality of life. Pulsed electromagnetic field (PEMF) stimulation represents an adjunct noninvasive treatment intervention that has been shown to improve successful fusion and patient outcomes following spinal surgery.Methods A prospective, multicenter study investigated PEMF as an adjunct therapy to lumbar spinal fusion procedures in patients at risk for pseudarthrosis. Patients with at least 1 of the following risk factors were enrolled: prior failed fusion, multilevel fusion, nicotine use, osteoporosis, or diabetes. Fusion status was determined by radiographic imaging, and patient-reported outcomes were also evaluated.Results A total of 142 patients were included in the analysis. Fusion status was assessed at 12 months follow-up where 88.0% (n = 125/142) of patients demonstrated successful fusion. Fusion success for patients with 1, 2+, or 3+ risk factors was 88.5%, 87.5%, and 82.3%, respectively. Significant improvements in patient-reported outcomes using the Short Form 36, EuroQol 5 Dimension (EQ-5D) survey, Oswestry Disability Index, and visual analog scale for back and leg pain were also observed compared with baseline scores (P < 0.001). A favorable safety profile was observed. PEMF treatment showed a positive benefit-risk profile throughout the 6-month required use period.Conclusions The addition of PEMF as an adjunct treatment in patients undergoing lumbar spinal surgery provided a high rate of successful fusion with significant improvements in pain, function, and quality of life, despite having risk factors for pseudarthrosis.Clinical Relevance PEMF represents a useful tool for adjunct treatment in patients who have undergone lumbar spinal surgery. Treatment with PEMF may result in improved fusion and patient-reported outcomes, regardless of risk factors.Trial Registration NCT03176303