Summary of patient and study demographics of patients receiving steroids after anterior cervical spine surgery.
| Author, Year | Design | Total number of patients included | Number of operative levels | Number of multilevel surgeries included, n (%) | Major indications for initial anterior cervical spinal surgery | Follow-up intervals | Demographics of Com rol Patient! | Demograiphics of Intervention Patients | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total Patients | Mean Age (in years) +/- SD | % Male | Control administered | Total patients | Mean Age +/- SD | % Male | Intervention administered | Steroid Dose Frequency | Steroid Dose Equivalent* | |||||||
| SYSTEMIC STEROIDS | ||||||||||||||||
| Pedram, 2003 | RCT | 236 | 1-5 | 66 (28) | Cervical canal stenosis, herniated disc, trauma | 24-36h PO | 158 | 47+/-15.3 (range: 15-88) | n/a | N/A | 78 | 47+/-12.3 (range: 17-83) | n/a | IV Methylprednisolone | 0h, 12h, 24h | 0.19 mg/kg |
| Nam, 2013 | RCT | 62 | 1 | 0 (0) | Cervical radiculopathy | Daily POD 0-5 | 22 | 48.8 | 80 | NS | High dose: 20 Low dose: 20 | High dose: 46.9 +/- 8.6 Low dose:45.6+/-7.3 | High dose: 55 Low dose: 70 | IV Dexamethasone | 0h, 24h, 48h | High dose: 20/10/10mg Low dose: 10/5/5mg |
| Song, 2014 | RCT | 40 | >3 | 40 (100) | Cervical radiculopathy, myelopathy | Daily POD 1-discharge | 20 | 57.3+/-11 (range: 29-77) | 80 | N/A | 20 | 59.9+/-10.3 (range: 42-47) | 70 | IV Methylprednisolone | 0h, 6h, 12h, 18h, 24h | 46.88mg |
| Jeyamohan, 2015 | RCT | 112 | ≥2 | 112 (100) | Cervical spondylosis | 1mo, 3mo, 6mo, 12mo, 24mo | 56 | 55 | 48.22 | NS | 56 | 54 | 58.93 | IV dexamethasone | IO, 6h, 12h, 18h, 24h | 0.20mg/kg IO, 0.06mg/ kg PO |
| LOCAL STEROIDS | ||||||||||||||||
| Lee, 2011 | RCT | 50 | 1-2 | 21 (42) | Cervical radiculopathy, myelopathy | POD 0, 2, 4, 2wk | 25 | 50.9 | 56 | N/A | 25 | 54.3 | 72 | RP triamcinolone | IO | 7.50mg |
| Cancienne, 2015 | Retrospective case control | 245754 | Short surgery:1-2 Long surgery: >3 | n/a | n/a | Within POD 0-90 | 243,662 | n/a | Short surgery: 47 Long surgery: 47.5 | N/A | 2092 | n/a | Short surgery: 40.3 Longsurgery: 42.1 | RP Triamcinolone or methylprednisolone | IO | 0.19mg, 1.88mg, 3.75mg, 7.5mg, 15mg |
| Koreckij, 2016 | Retrospective case control | 44 | 2-4 | 44 (100) | Cervical radiculopathy, myelopathy | POD 1, 6wk, 3mo | 22 | 57.6+/-9.9 | 50 | IV dexamethasone 10mg | 22 | 55.1 +/-7.9 | 54.5 | IV dexamethasone 10mg + RP methylprednisolone | IO | 15mg |
0h: immediately post-operatively; NS: Normal saline; IO: intraoperative; IV: intravenous; Long surgery: operated on 3 or more spinal levels; Mo: month; PO: post-operative; POD: post-operative day ; RP: retropharyngeal; Short surgery: operated on <3 spinal levels ; Wk: week.
↵* Dose equivalents relative to dexamethasone.