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Bone metastases as the first manifestation of a tumour

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Summary

We have reviewed 29 patients whose first sign of a tumour was a bone metastasis. Two primaries were identified, lung adenocarcinoma and uterine adenocarcinoma and in 2 cases a presumptive diagnosis of tumours of the breast and prostate was made. The mean survival time was 3 months. When bone metastases are found in the absence of a primary tumour, investigation must include a clinical history, physical examination, routine laboratory tests and chest radiographs. Mammography should be done in women, particularly when there are palpable axillary nodes. Abdominal CT scanning and bronchoscopy should only be undertaken when there is a clinical indication.

Résumé

Revue de 29 dossiers de malades chez qui le premier signe de néoplasie était une métastase osseuse. Deux des cancers primitifs ont pu être identifiés: l'un du poumon et l'autre de l'utérus, et dans deux cas on a posé le diagnostic présumé de tumeur du sein et de la prostate. Quand on découvre une métastase osseuse et que le cancer primitif n'est pas connu le bilan doit comporter une anamnèse, un examen clinique, les tests habituels de laboratoire et des radiographies pulmonaires. Une mammographie peut être demandée chez la femme, surtout s'il existe une adénopathie axillaire palpable. On ne pratiquera un examen tomodensitométrique de l'abdomen et une bronchoscopie que si des arguments cliniques les justifient.

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Barón, M.G., de la Gándara, I., Espinosa, E. et al. Bone metastases as the first manifestation of a tumour. International Orthopaedics 15, 373–376 (1991). https://doi.org/10.1007/BF00186882

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