Skip to main content

Advertisement

Log in

Prevention of venous thromboembolism in spinal surgery

  • Review
  • Published:
European Spine Journal Aims and scope Submit manuscript

Abstract

Deep vein thrombosis (DVT), and its most feared complication, pulmonary embolism (PE), still have a high incidence with high risk for patients’ health. Proven prophylactic measures are available but are generally underused, and DVT is still considered the most common cause of preventable death among hospitalized patients. The rationale for prophylaxis of venous thromboembolism is based on the clinically silent nature of the disease, the relatively high prevalence among hospitalized patients and the potentially tragic consequences of a missed diagnosis. During the last 15–20 years, spine surgery has changed radically, developing into a well-defined area of specialist surgery, and some attention is now being given to DVT events in spine surgery. The incidence of DVT during spine surgery is not documented in the literature, because only case reports or retrospective studies are reported. It would therefore be very helpful to initiate a multicenter study in order to understand this problem better and to develop, if possible, some guidelines on prophylactic measures in spine surgery. In doing so, we need to consider each patient’s pattern, any risk factors and every kind of surgical technique related to DVT, in order to improve the outcome of the patient and to reduce any medicolegal problems that could arise from a thrombotic complication or an epidural hematoma, with its high potential for irreversible consequences.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Agnelli G (1999) Prevention of venous thromboembolism after neurosurgery. Thromb Haemost 82:925–930

    CAS  PubMed  Google Scholar 

  2. Agnelli G, Sonaglia F (2000) Prevention of venous thromboembolism. Thromb Res 97:V49–V62

    Article  CAS  PubMed  Google Scholar 

  3. Agnelli G, Piovella F, Buoncristiani P, Severi P, Pini M, D’Angelo A, Beltrametti C, Damiani M, Andrioli GC, Pugliese R, Iorio A, Brambilla G (1998) Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. N Engl J Med 339:80–85

    Google Scholar 

  4. Agnelli G, Mancini GB, Biagini D (2000) The rationale for long-term prophylaxis of venous thromboembolism. Orthopedics 23 [Suppl 6]:643–646

  5. Andreshak TG, An HS, Hall J, Stein B (1997) Lumbar spine surgery in the obese patient. J Spinal Disord 10:376–379

    CAS  PubMed  Google Scholar 

  6. Ansari S, Warwick D, Ackroid CE (1997) Incidence of fatal pulmonary embolism after 1390 knee arthroplasties without routine prophylactic anticoagulation, except in high-risk cases. J Arthroplasty 12:599–602

    CAS  PubMed  Google Scholar 

  7. Arai Y, Shitoto K, Muta T, Kurosawa H (1999) Pulmonary thromboembolism after spinal instrumentation surgery. J Orthop Sci 4:380–383

    Article  CAS  PubMed  Google Scholar 

  8. Arcelus JI, Caprini JA, Reyna JJ (2000) Finding the right fit: effective thrombosis risk stratification in orthopedic patients. Orthopedics 23 [Suppl 6]:633–638

  9. Asano H, Matsubara M, Suzuki K, Morita S, Shiinomiya K (2001) Prevention of pulmonary embolism by a foot sole pump. J Bone Joint Surg Br 83:1130–1132

    Article  CAS  PubMed  Google Scholar 

  10. Axelrod DA, Wakefield TW (2001) Future directions in antithrombotic therapy: emphasis on venous thromboembolism. J Am Coll Surg 192:641–651

    Article  CAS  PubMed  Google Scholar 

  11. Benko T, Cooke EA, McNally MA, Mollan RAB (2001) Graduated compression stockings. Knee length or thigh length? Clin Orthop 383:197–203

    PubMed  Google Scholar 

  12. Benz RJ, Ibrahim ZG, Afshar P, Garfin SR (2001) Predicting complications in elderly patients undergoing lumbar decompression. Clin Orthop 384:116–121

    PubMed  Google Scholar 

  13. Bostrom S, Holmgren E, Jonsson O, Lindberg S, Lindstrom B, Winso L, Zachrisson B (1986) Post-operative thromboembolism in neurosurgery. A study on the prophylactic effect of calf muscle stimulations plus Dextran compared to low-dose heparin. Acta Neurochir 80:83–89

    CAS  Google Scholar 

  14. Brown CA, Eismont FJ (1998) Complications in spinal fusion. Orthop Clin North Am 29:679–699

    CAS  PubMed  Google Scholar 

  15. Buehler KO, D’Lima DD, Petersilge WJ (1999) Late deep venous thrombosis and delayed weightbearing after total hip arthroplasty. Clin Orthop 361:123–130

    Google Scholar 

  16. Cain JE, Major MR, Lauerman WC, West JL, Wood KB, Fueredi GA (1995) The morbidity of heparin therapy after development of pulmonary embolus in patients undergoing thoracolumbar or lumbar spinal fusion. Spine 20:1600–1603

    PubMed  Google Scholar 

  17. Catre MG (1997) Anticoagulation in spinal surgery. A critical review of the literature. Can J Surg 40:413–419

    CAS  PubMed  Google Scholar 

  18. Chasan-Taber L, Stampfer MJ (1998) Epidemiology of oral contraceptives and cardiovascular disease. Ann Intern Med 128:467–477

    CAS  PubMed  Google Scholar 

  19. Clagett GP, Anderson FA, Levine MN, Salzman EW, Wheeler HB (1992) Prevention of venous thromboembolism. Chest [Suppl] 102:391–407

  20. Clagett GP, Anderson FA, Geerts W, Heit JA, Knudson M, Lieberman JR, Merli GJ, Wheeler HB (1998) Prevention of venous thromboembolism. Chest [Suppl] 114:531–560

  21. Collins R, Scrimgeour A, Yusuf S (1988) Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin: overview of results of randomised trials in general, orthopaedic, and urologic surgery. N Engl J Med 318:1162–1173

    CAS  PubMed  Google Scholar 

  22. Colwell CW (2001) Low molecular weight heparin prophylaxis in total knee arthroplasty. The answer. Clin Orthop 392:245–248

    PubMed  Google Scholar 

  23. Comp PC, Spiro TE, Friedman RJ, Whitsett TL, Johnson GJ, Gardiner Jr GA, Landon GC, Jové M (2001) Prolonged Enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement. J Bone Joint Surg Am 83:336–345

    Google Scholar 

  24. Consortium for Spinal Cord Medicine (1997) Prevention of thromboembolism in spinal cord injury. J Spinal Cord Med 20:259–283

    PubMed  Google Scholar 

  25. Costantini S, Ashkenazi E, Shoshan Y, Israel Z, Umansky F (1992) Thoracic hematomyelia secondary to Coumadin anticoagulant therapy: a case report. Eur Neurol 32:109–111

    CAS  PubMed  Google Scholar 

  26. Dahl OE, Gudmundsen TE, Haukeland L (2000) Late occurring clinical deep vein thrombosis in joint-operated patients. Acta Orthop Scand 71:47–50

    Article  CAS  PubMed  Google Scholar 

  27. Dahl OE, Bergqvist D, Cohen AT, Frostick SP, Hull RD (2001) Low-molecular-weight heparin as prophylaxis against thromboembolism after total hip replacement. The never-ending story? Acta Orthop Scand 72:198–204

    Article  PubMed  Google Scholar 

  28. De Vivo MJ, Krause JS, Lammertse DP (1999) Recent trends in mortality and causes of death among persons with spinal cord injury. Arch Phys Med Rehabil 80:1411–1419

    PubMed  Google Scholar 

  29. Dearborn JT, Hu SS, Tribus CB, Bradford DS (1999) Thromboembolic complications after major thoracolumbar spine surgery. Spine 24:1471–1476

    Article  PubMed  Google Scholar 

  30. Decousus H, Marchal C, Bonnardot JP, Elias A (1992) Frequence de la maladie thromboembolique en fonction des types de chirurgie. Ann Fr Anesth Reanim 11:244–251

    CAS  PubMed  Google Scholar 

  31. Desbordes JM, Mesz M, Maissin F, Bataille B, Guenot M (1993) Etude multicentrique retrospective de la prevention des complications thromboemboliques apres chirurgie discale lombaire. Neurochirurgie 39:178–181

    CAS  PubMed  Google Scholar 

  32. Dunn AS, Schechter C, Gotlin A, Vomvolakis D, Jacobs E, Sacks HS, Coller B (2001) Outpatient treatment of deep venous thrombosis in diverse inner-city patients. Am J Med 110:458–462

    Article  CAS  PubMed  Google Scholar 

  33. Falanga A, Rickles FR (1999) Pathophysiology of the thrombophilic state in the cancer patient. Semin Thromb Hemost 25:239–243

    PubMed  Google Scholar 

  34. Ferree BA (1994) Deep venous thrombosis following lumbar laminotomy and laminectomy. Orthopedics 17:35–38

    CAS  PubMed  Google Scholar 

  35. Ferree BA, Wright AM (1993) Deep venous thrombosis following posterior lumbar spinal surgery. Spine 18:1079–1082

    CAS  PubMed  Google Scholar 

  36. Ferree BA, Stern PJ, Jolson RS, Roberts JM, Kahn A III (1993) Deep venous thrombosis after spinal surgery. Spine 18:315–319

    CAS  PubMed  Google Scholar 

  37. Fitzgerald Jr RH, Spiro TE, Trowbridge AA, Gardiner Jr GA, Whitsett TL, O’Connell MB, Ohar JA, Young TR (2001) Prevention of venous thromboembolic disease following primary total knee arthroplasty. A randomized, multicenter, open-label, parallel-group comparison of enoxaparin and warfarin. J Bone Joint Surg Am 83:900–906

    Google Scholar 

  38. Fujita T, Kostuik JP, Huckell CB, Sieber AN (1998) Complications of spinal fusion in adult patients more than 60 years of age. Orthop Clin North Am 29:669–678

    CAS  PubMed  Google Scholar 

  39. Geerts WH, Code KI, Jay RM (1994) A prospective study of VTE after major trauma. N Engl J Med 331:1601–1606

    Article  CAS  PubMed  Google Scholar 

  40. Geerts WH, Heit JA, Clagett GP, Pineo GF, Colwell CW, Anderson FA, Wheeler HB (2001) Prevention of venous thromboembolism. Chest [Suppl] 119:132–175

  41. Gillespie W, Murray D, Gregg PJ, Warwick D (2000) Prophylaxis against deep-vein thrombosis following total hip replacement: risks and benefits of prophylaxis against venous thromboembolism in orthopaedic surgery. J Bone Joint Surg Br 82:475–479

    Article  CAS  PubMed  Google Scholar 

  42. Gillies TE, Ruckley CV, Nixon SJ (1996) Still missing the boat with fatal pulmonary embolism. Br J Surg 83:1394–1395

    CAS  PubMed  Google Scholar 

  43. Grady D, Wenger NK, Herrington D, Khan S, Furberg C, Hunninghake D, Vittinghoff E, Hulley S (2000) Heart and Estrogen/Progestin Replacement Study Research Group. Postmenopausal hormone therapy increased risk for venous thromboembolic disease. Ann Intern Med 132:689–696

    CAS  PubMed  Google Scholar 

  44. Haas S (2000) Deep vein thrombosis: beyond the operating table. Orthopedics 23 [Suppl 6]:629–632

  45. Hackenberg L, Liljenqvist U, Halm H, Winkelmann W (2001) Occlusion of the left common iliac artery and consecutive thromboembolism of the left popliteal artery following anterior lumbar interbody fusion. J Spinal Disord 14:365–368

    Article  CAS  PubMed  Google Scholar 

  46. Haentjens P (2000) Venous thromboembolism after total hip arthroplasty. A review of incidence and prevention during hospitalisation and after hospital discharge. Acta Orthop Belg 66:1–8

    Google Scholar 

  47. Haentjens P, Lemaire R (2000) A pragmatic approach to prophylaxis of thromboembolic complications in orthopaedic surgery. Editions Scientifiques et Medicales Elsevier SAS (Paris), Surgical Techniques in Orthopaedics and Traumatology 55–010-D-30

  48. Hamilton MG, Hull RD, Pineo GF (1994) Venous thromboembolism in neurosurgery and neurology patients: a review. Neurosurgery 34:280–296

    CAS  PubMed  Google Scholar 

  49. Heit JA (2001) Low-molecular-weight heparin: the optimal duration of prophylaxis against postoperative venous thromboembolism after total hip or knee replacement. Thromb Res 101:V163–V173

    Article  CAS  PubMed  Google Scholar 

  50. Hull RD (2000) New insights into extended prophylaxis after orthopaedic surgery. The North American Fragmin Trial experience. Haemostasis 30 [Suppl 2]:95–100

  51. Hull RD, Brant RF, Pineo GF (1999) Preoperative vs postoperative initiation of low molecular weight heparin prophylaxis against VTE in patients undergoing elective hip replacement. Arch Intern Med 159:137–141

    Article  CAS  PubMed  Google Scholar 

  52. Hull RD, Pineo GF, MaC Isaac S (2001) Low-molecular-weight heparin prophylaxis. Preoperative versus postoperative initiation in patients undergoing elective hip surgery. Thromb Res 101:V155–V162

    Article  CAS  PubMed  Google Scholar 

  53. Janku GV, Paiement GD, Green HD (1996) Prevention of venous thromboembolism in orthopaedics in the United States. Clin Orthop 325:313–321

    PubMed  Google Scholar 

  54. Kakkar AK, Williamson RCN (1999) Prevention of VTE in cancer patients. Semin Thromb Hemost 25:239–243

    PubMed  Google Scholar 

  55. Kearon C, Hirsch J (1995) Starting prophylaxis for VTE postoperatively. Arch Intern Med 155:366–372

    Article  CAS  PubMed  Google Scholar 

  56. Khazim R, Boos N, Webb JK (1998) Progressive thrombotic occlusion of the left common iliac artery after anterior lumbar interbody fusion. Eur Spine J 7:239–241

    CAS  PubMed  Google Scholar 

  57. Knop C, Bastian L, Lange U, Oeser M, Zdiiichavsky M, Blauth M (2002) Complications in surgical treatment of thoracolumbar injuries. Eur Spine J 11:214–226

    Article  CAS  PubMed  Google Scholar 

  58. Kozak JA, O’Brien JP (1990) Simultaneous combined anterior and posterior fusion: an independent analysis of a treatment for disabled low-back pain patient. Spine 15:322–328

    CAS  PubMed  Google Scholar 

  59. Lee AYY, Levine MN (1999) The thrombophilic state induced by therapeutic agents in the cancer patient. Semin Thromb Hemost 25:137–145

    CAS  PubMed  Google Scholar 

  60. Lee HM, Suk KS, Moon SH, Kim DJ, Wang JM, Kim NH (2000) Deep vein thrombosis after major spinal surgery. Incidence in East Asian population. Spine 25:1827–1830

    Article  CAS  PubMed  Google Scholar 

  61. Marsicano J, Mirovsky Y, Remer S, Bloom N, Neuwirth M (1994) Thrombotic occlusion of the left common iliac artery after an anterior retroperitoneal approach to the lumbar spine. Spine 19:357–359

    CAS  PubMed  Google Scholar 

  62. Matzsch T (2000) Thromboprophylaxis with low-molecular-weight heparin: economic considerations. Haemostasis 30 [Suppl 2]:141–145

    Google Scholar 

  63. Mollan R (2000) Deep venous thrombosis: prophylaxis and treatment. Editions Scientifiques et Medicales Elsevier SAS (Paris), Surgical Techniques in Orthopaedics and Traumatology, 55–010-D-10

    Google Scholar 

  64. Muntz JE (2000) Deep vein thrombosis and pulmonary embolism in the perioperative patient. Am J Managed Care 6 [Suppl 20]:1045–1052

  65. Murray DW, Britton AR, Bulstrode CJK (1996) Thromboprophylaxis and death after total hip replacement. J Bone Joint Surg Br 78:863–870

    Article  CAS  PubMed  Google Scholar 

  66. National Institute of Health—Thrombosis and Embolism—Consensus Conference (1986) Prevention of venous thrombosis and pulmonary embolism. JAMA 256:744–749

    PubMed  Google Scholar 

  67. Nicolaides AN, et al (1997) Prevention of venous thromboembolism. Int Angiol 16:3–38

    PubMed  Google Scholar 

  68. Nurmohamed MT, Rosendaal FR, Buller HR, Dekker E, Hommes DW, Vandenbroucke JP, Briet E (1992) Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis. Lancet 340:152–156

    Article  CAS  PubMed  Google Scholar 

  69. Nurmohamed MT, van Riel AM, Henkes CMA, Koopman MMW, Que GTH, d’Azemar P, Buller HR, ten Cate JW, Hoek JA, van der Meer J, van der Heul C, Turpie AGG, Haley S, Sicurella J, Gent M (1996) Low molecular weight heparin and compression stockings in the prevention of venous thromboembolism in neurosurgery. Thromb Haemost 75:233–238

    CAS  PubMed  Google Scholar 

  70. Oda T, Fuji T, Fujita S, Kanemitsu N (2000) Deep venous thrombosis after posterior spinal surgery. Spine 25:2962–2967

    Article  CAS  PubMed  Google Scholar 

  71. O’Shaughnessy DF (2000) Low-molecular-weight heparins in the prophylaxis and treatment of thrombo-embolic disease. Hematology 4:373–380

    CAS  PubMed  Google Scholar 

  72. Prestar FJ (1992) Prevention of thromboembolism complications with low molecular weight heparin in microneurosurgical lumbar intervertebral disk operations. Neurochirurgia 35:1–4

    CAS  PubMed  Google Scholar 

  73. Pulmonary Embolism Prevention (PEP) Trial Collaborative Group (2000) Prevention of pulmonary embolism and deep vein thrombosis with low-dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet 355:1295–1302

    Article  PubMed  Google Scholar 

  74. Ramirez LF, Thisted R (1989) Complications and demographic characteristics of patients undergoing lumbar discectomy in community hospitals. Neurosurgery 25:226–231

    CAS  PubMed  Google Scholar 

  75. Raskas DS, Delamarter RB (1997) Occlusion of the left iliac artery after retroperitoneal exposure of the spine. Clin Orthop 338:86–89

    Google Scholar 

  76. Rasmussen MS, Wille-Jorgensen P, Jorgensen LN (1995) Postoperative fatal pulmonary embolism in a general surgical department. Am J Surg 169:214–216

    Article  CAS  PubMed  Google Scholar 

  77. Ravelli V, Marconi F, Lutzemberger L, Marini C, Di Ricco G, Genovesi M (1992) Il rischio di embolia polmonare in neurochirurgia. Minerva Anestesiol 58 [Suppl 1]:173–181

    Google Scholar 

  78. Rokito SE, Schwartz MC, Neuwirth MG (1996) Deep vein thrombosis after major reconstructive spinal surgery. Spine 21:853–859

    Article  CAS  PubMed  Google Scholar 

  79. Rosendaal FR (1999) Risk factor for venous thrombotic disease. Thromb Haemost 82:610–619

    CAS  PubMed  Google Scholar 

  80. Salvati EA, Pellegrini VD, Sharrock NE, Lotke PA, Murray DW, Potter H (2000) Recent advances in venous thromboembolic prophylaxis during and after total hip replacement. J Bone Joint Surg Am 82:252–270

    CAS  PubMed  Google Scholar 

  81. Scavarda D, Peruzzi P, Bazin A (1997) Hematomes extra-duraux rachidiens post-operatoires. Quatorze observations. Neurochirurgie 43:220–227

    CAS  PubMed  Google Scholar 

  82. Silverstein MD, Heit JA, Mohr DN (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 158:585–593

    CAS  PubMed  Google Scholar 

  83. Smith MD, Bressler EL, Lonstein JE, Winter R, Pinto MR, Denis F (1994) Deep venous thrombosis and pulmonary embolism after major reconstructive operations on the spine. A prospective analysis of three hundred and seventeen patients. J Bone Joint Surg Am 76:980–985

    CAS  PubMed  Google Scholar 

  84. Spain DA, Richardson JD, Polk HC, Bergamini TM, Wilson MA, Miller FB (1997) Venous thromboembolism in the high-risk trauma patient: do risks justify aggressive screening and prophylaxis? J Trauma 42:463–469

    CAS  PubMed  Google Scholar 

  85. Spanier DE, Stambough JL (2000) Delayed postoperative epidural hematoma formation after heparinization in lumbar spinal surgery. J Spinal Disord 13:46–49

    Article  CAS  PubMed  Google Scholar 

  86. Stolke D, Sollmann WP, Seifert V (1989) Intra- and postoperative complications in lumbar disc surgery. Spine 14:56–59

    CAS  PubMed  Google Scholar 

  87. Thromboembolic Risk Factors (THRIFT) Consensus Group (1992) Risk of and prophylaxis for VTE in hospital patients. BMJ 305:567–574

    PubMed  Google Scholar 

  88. Uden A (1979) Thromboembolic complications following scoliosis surgery in Scandinavia. Acta Orthop Scand 50:175–178

    CAS  PubMed  Google Scholar 

  89. Warwick D, Bannister GC, Glew D, Mitchelmore A, Thornton M, Peters TJ, Brookes S (1995) Perioperative low-molecular-weight heparin. Is it effective and safe? J Bone Joint Surg Br 77:715–719

    CAS  PubMed  Google Scholar 

  90. Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L, Clement C, Robinson KS, Lewandowski B (1997) Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet 350:1795–1798

    Article  CAS  PubMed  Google Scholar 

  91. Wen DY, Hall WA (1998) Complications of subcutaneous low-dose heparin therapy in neurosurgical patients. Surg Neurol 50:521–525

    Article  CAS  PubMed  Google Scholar 

  92. West JL (1998) Deep vein thrombosis in spinal surgery. Curr Opin Orthop 9:43–47

    Google Scholar 

  93. West JL, Anderson LD (1992) Incidence of deep vein thrombosis in major adult spinal surgery. Spine [Suppl] 17:254–257

    Google Scholar 

  94. Wisowski DK, Talarico R, Bacsanyii J, Botstein P (1998) Spinal and epidural hematoma and low-molecular-weight heparin. Letter to the editor. N Engl J Med 338:1774

    Google Scholar 

  95. Wood KB, Kos PB, Abnet JK, Ista C (1997) Prevention of deep-vein thrombosis after major spinal surgery: a comparison study of external devices. J Spinal Disord 10:209–214

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Brambilla.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brambilla, S., Ruosi, C., La Maida, G.A. et al. Prevention of venous thromboembolism in spinal surgery. Eur Spine J 13, 1–8 (2004). https://doi.org/10.1007/s00586-003-0538-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00586-003-0538-7

Keywords

Navigation