Abstract
The objective of the present study was to investigate the natural history of intradural–extramedullary spinal cord tumors. Nine cases of intradural–extramedullary tumors were observed over the 2 years. The physical and magnetic resonance imaging (MRI) examination were performed in the first examination and every other year. Tumors were classified as the schwannoma type and the meningioma type based on the MRI findings. The tumor volume was calculated by the craniocaudal length on a sagittal image and maximum transverse diameter on an axial image of MRI, every year. The annual growth rate, which was defined as the change in the volume each year compared to the volume of the previous year, was examined. There were six cases in the schwannoma type and three cases in the meningioma type. The schwannoma type tumors presented several growth patterns: unchanging, continuous slight growth, and initial slight growth followed by rapid growth during the observation period (6.7 ± 2.7 years), while the meningioma type tumors presented the continuous growth pattern during the observation period (4.3 ± 2.5 years). The average annual growth rate was 2.3 ± 5.5% in the schwannoma type and 7.0 ± 8.5% in the meningioma type. Schwannoma type tumors showed relatively less change in their size and would be observed for a longer time.
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References
Rosenberg SI (2000) Natural history of acoustic neuromas. Laryngoscope 110:497–508
Yoshimoto Y (2005) Systematic review of the natural history of vestibular schwannoma. J Neurosurg 103:59–63
Nikolopoulos TP, Fortnum H, O’Donoghue G, Baguley D (2010) Acoustic neuroma growth: a systematic review of the evidence. Otol Neurotol 31:478–485
Olivero WC, Lister JR, Elwood PW (1995) The natural history and growth rate of asymptomatic meningiomas: a review of 60 patients. J Neurosurg 83:222–224
Nakamura M, Roser F, Michel J, Jacobs C, Samii M (2003) The natural history of incidental meningiomas. Neurosurgery 53:62–70
Sughrue ME, Rutkowski MJ, Aranda D, Barani IJ, McDermott MW, Parsa AT (2010) Treatment decision making based on the published natural history and growth rate of small meningiomas. J Neurosurg 113:1036–1042
Ozawa H, Kokubun S, Masuda K, Kashimoto O, Sakurai M, Ishikawa T (1992) MRI of spinal cord tumor: differential diagnosis among neurinoma, neurifibroma and meningioma. In Japanese East Jpn J Clin Orthop 4:389–392
Collins VP, Loeffler RK, Tivey H (1956) Observations on growth rates of human tumors. Am J Roentgenol Radium Ther 76:988–1000
Schellinger KA, Propp JM, Villano JL, McCarthy BJ (2008) Descriptive epidemiology of primary spinal cord tumors. J Neurooncol 87:173–179
Engelhard HH, Villano JL, Porter KR, Stewart AK, Barua M, Barker FG, Newton HB (2010) Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina. J Neurosurg Spine 13:67–77
Tanaka Y, Kokubun S, Sato T, Ozawa H, Ishii Y, Yamazaki S (1999) Revision surgery for spinal cord tumors. In Japanese Orthop surg Traumatol 42:1425–1432
el-Mahdy W, Kane PJ, Powell MP, Crockard HA (1999) Spinal intradural tumours: part I-extramedullary. Br J Neurosurg 13:550–557
Parsa AT, Lee J, Parney IF, Weinstein P, McCormick PC, Ames C (2004) Spinal cord and intradural-extraparenchymal spinal tumors: current best care practices and strategies. J Neurooncol 69:291–318
Cheng MK (1982) Spinal cord tumors in the People’s Republic of China: a statistical review. Neurosurgery 10:22–24
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Ozawa, H., Onoda, Y., Aizawa, T. et al. Natural history of intradural–extramedullary spinal cord tumors. Acta Neurol Belg 112, 265–270 (2012). https://doi.org/10.1007/s13760-012-0048-7
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DOI: https://doi.org/10.1007/s13760-012-0048-7