Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

https://doi.org/10.1016/j.bbabio.2016.03.012Get rights and content
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Highlights

  • Succinate is at the cross-road of several metabolic pathways.

  • Succinate is involved in the formation and elimination of reactive oxygen species.

  • Succinate is also involved in epigenetics and tumorigenesis.

  • Succinate plays a role in endo- and paracrine modulation and inflammation.

  • We review succinate as a metabolite or a signal.

Abstract

Succinate is an important metabolite at the cross-road of several metabolic pathways, also involved in the formation and elimination of reactive oxygen species. However, it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis, signal transduction, endo- and paracrine modulation and inflammation. Here we review the pathways encompassing succinate as a metabolite or a signal and how these may interact in normal and pathological conditions.1

Keywords

Substrate-level phosphorylation
Cancer
HIF1-alpha
Succinate dehydrogenase
Succinate receptor

Cited by (0)

1

“This article is part of a Special Issue entitled ‘EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2–6, 2016’, edited by Prof. Paolo Bernardi”.