Opinions have varied regarding the optimal treatment of an unstable Hangman's fracture. C2 pedicle screw instrumentation is a biomechanically strong fixation which although done through a simple posterior approach, is a technically demanding procedure. This prospective, non-randomized multicentre study included 15 consecutive patients with displaced type II traumatic spondylolisthesis of the axis. There were nine males and six females with a mean age of 37 years at surgery. The cause of injury was a road traffic accident in 11 patients and a fall from height in 4 patients. All patients had a single stage reduction and direct transpedicular screw fixation through the C2 pedicles. During follow-up, clinical evaluation and plain X-rays were performed at each visit; at 6-month follow-up, additional dynamic lateral flexion/extension views and a CT scan were performed. The average follow-up period was 32 months (range 25-56 months). At final follow-up, all patients were asymptomatic and regained a good functional outcome with no limitation of range of motion; all the patients showed solid union with no implant failure. There were no neurological complications. At 6-month follow-up, CT evaluation showed fusion in all patients and an adequate position of 28 screws. Two pedicle screws (6.6%) showed minimal (defined as <2 mm) intrusion; one into the spinal canal and the other into the vertebral foreamen. Transpedicular screw fixation through the C2 pedicles is a safe and effective method in treating type II traumatic spondylolisthesis of the axis resulting in good clinical and radiological outcomes. Adequate reduction was achieved and motion segments were preserved with its use.