Abstract
Succinate is an important metabolite at the cross-road of several metabolic pathways, also involved in the formation and elimination of reactive oxygen species. However, it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis, signal transduction, endo- and paracrine modulation and inflammation. Here we review the pathways encompassing succinate as a metabolite or a signal and how these may interact in normal and pathological conditions.(1).
Keywords:
Cancer; HIF1-alpha; Substrate-level phosphorylation; Succinate dehydrogenase; Succinate receptor.
Copyright © 2016 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Carcinogenesis / genetics
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Carcinogenesis / metabolism*
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Carcinogenesis / pathology
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Gene Expression Regulation, Neoplastic*
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Humans
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Hypoxia / genetics
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Hypoxia / metabolism*
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Hypoxia / pathology
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
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Metabolic Networks and Pathways / genetics
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Mutation
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Neoplasms / genetics
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Neoplasms / metabolism*
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Neoplasms / pathology
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Paracrine Communication / genetics
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Protein Subunits / genetics
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Protein Subunits / metabolism
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Reactive Oxygen Species / metabolism
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Receptors, G-Protein-Coupled / genetics
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Receptors, G-Protein-Coupled / metabolism
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Signal Transduction
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Succinate Dehydrogenase / genetics
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Succinate Dehydrogenase / metabolism*
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Succinic Acid / metabolism
Substances
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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Protein Subunits
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Reactive Oxygen Species
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Receptors, G-Protein-Coupled
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Succinic Acid
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Succinate Dehydrogenase