The epidermal growth factor receptor (EGFR) gene is amplified in 40% of malignant gliomas,
and the amplified genes are frequently rearranged. We have characterized the genetic …

Primary malignant gliomas from 63 patients were analyzed to determine the relationship
between amplification of the gene encoding the epidermal growth factor receptor (EGFR) and …

The epidermal growth factor receptor has received much interest as a target for various
antineoplastic agents, but a complication is that many normal tissues also express this receptor. …

THE protein Grb2 plays a central role in signalling by receptor protein-tyrosine kinases 1,2 ,
where its SH2 domain binds to the receptor and its two SH3 domains link to effectors. One …

Fluorescence microscopy with 7-nitrobenz-2-oxa-3-diazole phallacidin was used to survey
vertebrate tissues for actin filament bundles comparable to the stress fibers of cultured cells. …

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma.
The gene is expressed at high levels in the original tumor and its derived cell line and is …

Twin studies have provided the basis for genetic and epidemiological studies in human
complex traits 1 , 2 . As epigenetic factors can contribute to phenotypic outcomes, we conducted …

Nerve growth factor (NGF) prevents apoptosis through stimulation of the TrkA receptor
protein tyrosine kinase. The downstream activation of phosphatidylinositol 3-kinase (PI 3-kinase) …

Despite molecular biological advances in understanding human cancers, translation into
therapy has been less forthcoming; targeting neoplastic cells still requires that tumor-specific …

The most frequently found alteration of the epidermal growth factor receptor (EGFR) in human
tumors is a deletion of exons 2–7. This receptor, termed EGFRvIII, can transform NIH 3T3 …