Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes

L Song, N Fu, BG Ernst, WH Lee, MO Frederick… - Nature …, 2020 - nature.com
Chiral nitriles and their derivatives are prevalent in pharmaceuticals and bioactive compounds.
Enantioselective alkene hydrocyanation represents a convenient and efficient approach …

Accelerated and Scalable C(sp3)–H Amination via Decatungstate Photocatalysis Using a Flow Photoreactor Equipped with High-Intensity LEDs

…, P García-Losada, C Mateos, MO Frederick… - ACS Central …, 2021 - ACS Publications
Carbon–nitrogen bonds are ubiquitous in biologically active compounds, prompting
synthetic chemists to design various methodologies for their preparation. Arguably, the ideal …

Highly stereoselective synthesis of novel α-haloenamides via a mild and efficient hydrohalogenation of ynamides

…, RP Hsung, H Coverdale, MO Frederick… - Organic …, 2003 - ACS Publications
A highly stereoselective preparation of novel chiral (E)-α-haloenamides under mild
conditions utilizing magnesium halide salts is described. This unexpected mild and efficient …

Pediatric scoliosis

F Mo, ME Cunningham - Current reviews in musculoskeletal medicine, 2011 - Springer
Pediatric scoliosis is a relatively uncommon condition typically first noticed due to altered
stature or by routine spine screenings by a school nurse or pediatrician. The formal diagnosis …

The First Stereoselective Ficini− Claisen Rearrangement Using Chiral Ynamides

JA Mulder, RP Hsung, MO Frederick, MR Tracey… - Organic …, 2002 - ACS Publications
The first asymmetric Ficini−Claisen rearrangement using chiral ynamides is described. At
relatively low temperatures, the Ficini−Claisen rearrangement can be efficiently promoted by p-…

Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1

…, G Petrovic, W Tang, MO Frederick… - Journal of the …, 2006 - ACS Publications
The molecular structure of azaspiracid-1, a neurotoxin isolated from mussels, has been
elucidated by total synthesis which also enriched its supplies. The degradatively derived …

Highly Stereoselective Saucy− Marbet Rearrangement Using Chiral Ynamides. Synthesis of Highly Substituted Chiral Homoallenyl Alcohols

MO Frederick, RP Hsung, RH Lambeth, JA Mulder… - Organic …, 2003 - ACS Publications
FrederickFrederick - Department of Chemistry, University of Minnesota, Minneapolis,
Minnesota 55455 … Frederick, Robert H. Lambeth, Jason A. Mulder, Michael R. …

Kilogram-scale GMP manufacture of tirzepatide using a hybrid SPPS/LPPS approach with continuous manufacturing

MO Frederick, RA Boyse, TM Braden… - … Process Research & …, 2021 - ACS Publications
The large-scale manufacture of complex synthetic peptides is challenging due to many factors
such as manufacturing risk (including failed product specifications) as well as processes …

[PDF][PDF] Overview of HR Analytics to maximize Human capital investment

MO Fred, UM Kinange - … Journal of Advance Research and Innovative …, 2015 - academia.edu
The aim of this paper was to find out what HR analytics holds the promise of both elevating
the status of the HR profession and serving as a source of competitive advantage for …

Structural Revision and Total Synthesis of Azaspiracid‐1, Part 1: Intelligence Gathering and Tentative Proposal

…, W Tang, G Petrovic, MO Frederick… - Angewandte …, 2004 - Wiley Online Library
Structure 1-i (Figure 1, absolute stereochemistry and relative stereochemistry between ABCDE
and FGHI domains unknown) was proposed in 1998, on the basis of NMR spectroscopic …