Efficacy of different drug classes used to initiate antihypertensive treatment in black subjects: results of a randomized trial in Johannesburg, South Africa
…, ZP Valtchanova, E Libhaber, GP Candy… - Archives of Internal …, 2001 - jamanetwork.com
Background Thiazides are recommended to initiate antihypertensive drug treatment in black
subjects. Objective To test the efficacy of this recommendation in a South African black …
subjects. Objective To test the efficacy of this recommendation in a South African black …
Enuresis in South African children: prevalence, associated factors and parental perception of treatment
MW Fockema, GP Candy, D Kruger… - BJU …, 2012 - Wiley Online Library
… Children in the NE associated with DUI group were significantly younger than those in the
MNE group (P= 0.011). The prevalence of NE, MNE and NE associated with DUI showed a …
MNE group (P= 0.011). The prevalence of NE, MNE and NE associated with DUI showed a …
Association of left ventricular systolic performance and cavity size with angiotensin-converting enzyme genotype in idiopathic dilated cardiomyopathy
GP Candy, D Skudicky, UK Mueller… - The American journal of …, 1999 - Elsevier
The insertion–deletion (ID) polymorphism of the angiotensin-converting enzyme (ACE)
gene is a marker linked to differences in plasma and cardiac ACE activity as well as to an …
gene is a marker linked to differences in plasma and cardiac ACE activity as well as to an …
Cystatin C-and creatinine-based equations in the assessment of renal function in HIV-positive patients prior to commencing highly active antiretroviral therapy
…, HE van Deventer, GP Candy… - Annals of Clinical …, 2016 - journals.sagepub.com
Background We evaluated the accuracy and precision of creatinine- and cystatin C-based
prediction equations for estimating glomerular filtration rate compared to measured …
prediction equations for estimating glomerular filtration rate compared to measured …
Angiotensinogen gene promoter region variant modifies body size–ambulatory blood pressure relations in hypertension
…, GP Candy, R Brooksbank, EN Libhaber, P Sareli… - Circulation, 2002 - Am Heart Assoc
Background— The extent to which genes modify the relationship between risk factors for
hypertension and blood pressure (BP) is unclear. As angiotensinogen is expressed in adipose …
hypertension and blood pressure (BP) is unclear. As angiotensinogen is expressed in adipose …
An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy
…, D Skudicky, AJ Woodiwiss, GP Candy… - Cardiovascular …, 2002 - academic.oup.com
Objective: To assess whether renin–angiotensin–aldosterone (RAA) system gene
polymorphisms shown to be associated with alterations in the activity of the system, may predict …
polymorphisms shown to be associated with alterations in the activity of the system, may predict …
Establishment of a heterotypic 3D culture system to evaluate the interaction of TREG lymphocytes and NK cells with breast cancer
…, T Dix-Peek, R Duarte, GP Candy - Journal of Immunological …, 2015 - Elsevier
Three-dimensional (3D) culture approaches to investigate breast tumour progression are
yielding information more reminiscent of the in vivo microenvironment. We have established a …
yielding information more reminiscent of the in vivo microenvironment. We have established a …
Impact of renin-angiotensin-aldosterone system gene variants on the severity of hypertension in patients with newly diagnosed hypertension
…, GP Candy, R Brooksbank, P Sareli… - American journal of …, 2003 - academic.oup.com
Background: The severity of hypertension has prognostic significance. Previous studies
have assessed the relationship between renin-angiotensin-aldosterone system (RAAS) …
have assessed the relationship between renin-angiotensin-aldosterone system (RAAS) …
Myocardial stiffness is attributed to alterations in cross-linked collagen rather than total collagen or phenotypes in spontaneously hypertensive rats
…, J Tsotetsi, B Trifunovic, C Hartford, GP Candy… - Circulation, 1997 - Am Heart Assoc
Background The relative contributions of increases in myocardial collagen, collagen cross-linking,
and the ratio of type I to type III collagen to the stiff myocardium in hypertension were …
and the ratio of type I to type III collagen to the stiff myocardium in hypertension were …
Functional variants of the angiotensinogen gene determine antihypertensive responses to angiotensin-converting enzyme inhibitors in subjects of African origin
…, AD Tiago, GP Candy, E Libhaber, P Sareli… - Journal of …, 2006 - journals.lww.com
Objective To determine whether the response to angiotensin-converting enzyme inhibitor (ACEI)
monotherapy in subjects of African origin is determined by genetic variants within the …
monotherapy in subjects of African origin is determined by genetic variants within the …
