Lumbar disc degeneration is one of the leading causes of chronic low back pain. The
degenerative cascade is often initiated by an imbalance between catabolic and anabolic …

Spinal surgery is undergoing a major transformation toward a minimally invasive paradigm.
This shift is being driven by multiple factors, including the need to address spinal problems …

Strong forces are pushing minimally invasive spinal surgery (MISS) to the forefront of spine
care. Less-invasive surgical techniques have been enabled by a variety of technical …

Tumor-specific monoclonal antibodies (mAbs) have demonstrated efficacy in the clinic,
becoming an important approach for cancer immunotherapy. Due to its limited expression on …

OBJECTIVE Chronic subdural hematoma (cSDH) is a common and challenging pathology to
treat due to both the historically high recurrence rate following surgical evacuation and the …

Background Addition of anti‐GD2 antibody ch14.18 to the treatment of neuroblastoma has
improved outcomes. The most common side effect of ch14.18 is neuropathic pain, which may …

The human intervertebral disc (IVD) is a complex organ composed of fibrous and cartilaginous
connective tissues, and it serves as a boundary between 2 adjacent vertebrae. It provides …

Introduction Surgical decompression is standard care in the treatment of degenerative
spondylolisthesis in patients with symptomatic lumbar spinal stenosis, but there remains …

Given recent technological advances and advances in our understanding of cancer,
immunotherapy of cancer is being used with clear clinical benefit. The immunosuppression …

BACKGROUND: The management of spinal metastatic renal cell carcinoma (mRCC) is
controversial regarding extent of resection and radiation dosing. OBJECTIVE: To determine …